Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Radiosensitisation"”.
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Solid and hollow gold nanoparticles as radiosensitisers in combination with x-ray radiation and targeted radiopharmaceuticals
… gold nanoparticles have reported successful radiosensitisation only in combination with low kV radiation sources, but not with high kV or MV radiation. HGNs have been employed in photothermal ablation therapy, little work has been performed to investigate their potential as radiosensitisers, …
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Optimization of Gold Nanoparticles for Radiotherapy
… (2) the development of oligonucleotide-AuNPs for radiosensitisation. (1) It is shown that sugar-PEGamine coated AuNPs demonstrate selective uptake and toxicity toward skin cancer cells with an IC50 of 1 μg/ml [Au], without damaging normal skin cells at this concentration. Oxidative stress and …
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Physical and biological characterisation of clinically relevant combined MRI-radiation exposures with conventional and nanoparticle contrast agents
… decrease in the rate of tumour growth caused by radiosensitisation.<br/><br/>Results:<br/>Dosimetry measurements validated Alanine, Gafchromic Film and ionisation chambers to be reliable dosimeters in the presence of a magnetic field. SPIONs were found to have the lowest contrast enhancement, …
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Mitochondrial dynamics in the radiation response of cancer cells
… may, in part, be responsible for the observed radiosensitisation, as cells accumulate in a radiosensitive cell cycle phase. In addition, the finding that Mdivi-1 treatment induced micronuclei suggested that the radiosensitisation may result from the interaction of cytogenetic damage induced by …
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Creation and enhancement of a quantized hybrid computational model of cell cycle progression including DNA damage and repair mechanisms
… expansion of the model to include the radiosensitisation due to the treatment with citrate capped gold nanoparticles was achieved by collecting in vitro data from gold nanoparticle treated HUVEC cells before irradiation, HUVEC’s were used as they contain fully intact cell cycle damage …
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Enhancing the radio sensitivity of prostate cancer using RALA Gold nano-complexes
… Most importantly RALA-AuNP induced significant radiosensitisation at both research and clinically relevant energies at Au concentrations several orders of magnitude lower than previous literature. As such, the findings within this thesis extend our knowledge of radiosensitisers, in particular …