Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Radioresistance"”.
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Radioresistance in oral squamous cell carcinoma
… this thesis was to investigate the mechanism of radioresistance and create an in vitro model of a radioresistant oral squamous cell carcinoma. The methods of cell culture, microarray analysis and immunohistochemistry were employed to this end. Two novel radioresistant cell lines, PE-CAPJ41RR and …
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Overcoming radioresistance by targeting p21 in cancer
… the molecular mechanisms at the base of radioresistance is crucial to improve effectiveness of therapy. Radiation induced tumor regression is driven by DNA damages production and activation of downstream cellular responses mainly regulated by p53. The cyclin-dependent kinase inhibitor p21 …
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Dissecting Molecular Mechanisms of Radioresistance Using in Vitro and in Vivo Brain Tumor Model Systems
… This results in faster repair and increased radioresistance, both in vitro and in orthotopic GBM models. While activation of Akt by the loss of PTEN has similar results, data shows that PTEN loss reduces resistance to agents that induce replication-associated DSBs. This phenotype is due to …
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The role of CCR7 axis in facilitating chemoresistance, radioresistance and induction of cell proliferation in cancer
… proliferation and/or increased chemo- and radioresistance, and whether these effects may have a physiological/clinical relevance. Interestingly, CXCR4 involvement in cancer recurrence, metastasis and proliferation is already well established. Thus, it was used as a point of reference to …
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Sensitivity of Diffuse Reflectance Spectroscopy to Dose- and Depth-dependent Changes in Tumor Oxygenation after Radiation Therapy
… treatment outcome may be less favorable due to radioresistance processes happening within a tumor on the molecular level. Radioresistance remains a big challenge for modern oncology. The ability to identify radioresistance at the early stage of radiotherapy would help physicians to improve …
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Studies in Peroxiredoxin Hyperoxidation Sensitivity
… For example, Prxs contribute to chemo- and radioresistance in cancers, so by sensitizing a Prx to inactivation, it may be possible to resensitize cancer cells to therapy.
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Dissecting the Role of microRNAs in the Radiation Response of Human Prostate Cancer
… prostate cancer (PCa), although development of radioresistance limits its effectiveness. Mounting evidence supports the ability of microRNAs to interfere with different radioresistance-associated pathways, suggesting their potential as radiosensitizers. To identify miRNAs likely to be involved …
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The molecular effects of low dose fractionated radiation treatment on Ovarian Adenocarcinoma
… that could overcome the clinical problem of radioresistance. Recently, it has been shown in cell survival studies that low doses of radiation (less than 100cGy) induce an initial phase of hypersensitivity (HRS) to radiation in vitro. This HRS is most pronounced in radioresistant cells. A …
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Multi-modal molecular imaging of radiation therapy response in the tumour vascular microenvironment
… the strong relationship between hypoxia and radioresistance, PAI assessment of the tumour vascular microenvironment has the potential to detect radioresistance and response at much earlier time-points than currently achieved by shape measurements with conventional imaging modalities. In …
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Reactive Oxygen Species and P21 Waf1/Cip1 Are Both Essential For
… survival. One potential biomarker to determine radioresistance is <em>TP53</em>, whose alterations are predictive of poor radiation response. The following work shows that the p53 transcriptional target, p21, is crucial in initiating and maintaining senescence in HNSCC, through its ability to …
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Proteomic identification of putative biomarkers of radiotherapy resistance
… between expression of the 26S Proteasome and radioresistance in breast cancer.DiscussionA large number of DEPs which may be associated with radiotherapy resistance in breast, oral and rectal cancers have been identified using comparative proteomic platforms. The protein ubiquitination pathway …
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Prognostic and treatment predictive factors for radio- and chemotherapy resistance in breast cancer patients- a step towards personlized medicine
… result is the gene expression profile for “radioresistance” found in a patient cohort consisting of 100 lymph node negative patients operated with breast conservation surgery and either postoperative radiotherapy or not. The samples were analyzed with oligonucleotide array. A gene expression …
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Using high-content subcellular proteomics to identify x-ray-induced protein trafficking
… a potential suppression of ferroptosis, thus a radioresistance mechanism. However, this would require further validation with functional assays. According to our orthogonal proteomics data, changes in subcellular localisation of the proteins appeared to be relatively independent of protein …
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HIF-1alpha role in oxygen-dependent radio- and chemosensitivity
… role in our in vitro model of hypoxia-induced radioresistance whereas its contribution to oxygendependent sensitivity to cisplatin was less clear-cut. Although this behavior is likely to be conditioned by further biological and physical factors operating in vivo, it is consistent with the …
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Increased biopolymer pigment production in bacteria and fungi exposed to ionizing radiation
… may potentially have an important role in the radioresistance of the organisms⁵. For this reason, the Mediated Matter Group is conducting research both simulating and in space environments to understand the impact of radiation on biological systems and their adaptive strategies. In this work, …
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Characterizing in vitro propagation and radiation response of murine mammary stem cells
… Atm-ΔSRI heterozygous mice exhibited increased radioresistance. To our knowledge, this is the first study to examine the radiation response of mammary stem cells as mammospheres using Atm heterozygous mice carrying a known missense mutation found in human A-T. These studies demonstrated the …
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Understanding The Repair Mechanisms at Ionizing Radiation-induced Damage in The Human Genome
… in surviving cells could contribute to radioresistance and could be therapeutically targeted. In a separate study, we showed that there is a hierarchy in repair of DSBs by NHEJ followed by base excision repair of oxidized bases at IR-induced damage clusters, coordinated by scaffold …
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Development of a novel combination radio- chemotherapy for glioblastoma multiforme
… fumarate is capable of activating the chemo- and radioresistance factorNRF2. We believe that this is the first mechanistic interrogation of dimethyl fumarate being used to potentiate combined chemo-radiotherapy, however future work is needed before potential clinical deployment of dimethyl …
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Bacterial acid phosphatase and its application to waste remediation and metal recovery
… with Zr(IV) supplement assuming phosphatase radioresistance. The Serratia sp. phosphatase exists in two distinct isoforms (SP1 (radioresistant) and SP2 (radiosensitive)) which were purified and further characterised in this study. Both isoforms were found to have redox capability and were …
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Inactivation synergy between high energy neutrons and ⁶⁰Co gamma rays
… to dose enhancement ratios that increase with radioresistance. Multi-target parameters indicated that on a per gray basis, priming doses of p(66)/Be neutrons and ⁶⁰Co γ-rays induce comparative levels of sublethal damage. However, non-parametric analysis of the survival data showed that …
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