Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"Radiopharmaceuticals"”.
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In vitro comparison of methylene diphosphonate radiopharmaceuticals
… will be to investigate Methylene Diphosphonate radiopharmaceuticals for their binding efficiencies, stability, and subsequent changes due to varying technetium levels. </p>
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Functionalized isonitrile complexes of technetium as radiopharmaceuticals
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1987.
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Development of new radiopharmaceuticals targeting the Cholecystokinin 2 receptor
Il percorso di studi sperimentali del presente Ph.D è stato incentrato sullo sviluppo di radiofarmaci innovativi e sulla loro valutazione preclinica. Il progetto è stato inquadrato all’interno della “filiera del radiofarmaco” nata a Catania grazie alla collaborazione instaurata tra il Center for …
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Copper-64 radiopharmaceuticals for receptor-mediated tumor imaging and radiotherapy
This study investigated several somatostatin analogues labeled with copper-64 for imaging and targeted therapy of SSTr positive cancer. Among three new cross-bridged bifunctional chelators coupled to Y3-TATE, 64Cu-CB-TE2A-Y3-TATE had the most favorable tumor targeting properties. The introduction …
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Development of A Multi-Purpose Automated Synthesis Module For Production of Novel Pet Radiopharmaceuticals
<p>Among radiopharmaceuticals of positron emission tomography (PET), <sup>18</sup>F-Fluorodeoxyglucose (<sup>18</sup>F-FDG) made from commercialized automated synthesis module is the most frequently used in tumor diagnoses. But the false positive findings, such as infectious tissues and …
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Synthesis and preclinical evaluation of peptide receptor-targeted diagnostic and therapeutic radiopharmaceuticals for prostate cancer
… cells can be exploited for the development of radiopharmaceuticals that are selectively delivered to cancer cells for diagnostic imaging or therapeutic purposes. Parts of this dissertation explore the development and preclinical evaluation of a radiolabeled antagonist peptide conjugate (RM2 = …
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Solid and hollow gold nanoparticles as radiosensitisers in combination with x-ray radiation and targeted radiopharmaceuticals
Radiotherapy is currently employed in the treatment of 50% of cancer patients. Cancer's heterogeneous nature mean optimal use of radiotherapy will be through combination and targeted therapies. Studies investigating the radiosensitising potential of solid gold nanoparticles have reported successful …
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Direct bromine-80 or bromine-82 labelling of biomolecules via excitation labelling methods: preparation of radiopharmaceuticals
The direct decay induced ⁸²Br (or ⁸⁰Br) labelling by exposing the solid substrate molecules, such as deoxyuridine, L-tyrosine, guanosine, deoxycytodine, phenylalanine and acetic acid, to gaseous CF₃<sup>82m</sup>Br (or CF₃<sup>80m</sup>Br) was studied. The radiochemical yields of the brominated …
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Comprehensive integration of safety, optimization, and regulation in ¹⁷⁷Lu-based theranostic radiopharmaceuticals: from production to dose assessment
In recent decades, medical radioisotopes have transformed cancer diagnosis and treatment. The advent of theranostic radionuclides, enabling both diagnostic and targeted radiotherapy with a single radionuclide, merges two nuclear medicine fields, enhancing personalized targeted radiotherapy through …
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Technetium-Labeled Receptor-Specific Radiopharmaceuticals: Synthesis of oxorhenium(V) Mimics of Steroid Hormones Based on the Integrated Approach
Tetradentate oxorhenium(V) coordination motifs were subsequently investigated as possible modes by which the metal-chelate may be incorporated into a steroid-like structure. A novel amine amide thioether thiol (AATT) chelation paradigm was devised to replace the C and D rings of the steroid with a …
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Imaging Prostate Cancer: Design, Synthesis, and in Vivo Testing of Steroidal and Non-Steroidal Androgen Selective PET Radiopharmaceuticals
In addition to our non-steroidal work, we have designed and synthesized some high affinity steroidal compounds to probe the mechanism of androgen delivery to the cellular AR transcription mechanism. Sex hormone binding globulin (SHBG) binds testosterone, the principal circulating androgen, in high …
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Development of New Linking Chemistry with the fac-{Re(CO)3}+ Core for Eventual Applications in Radiopharmaceuticals in Imaging and Therapy
The facile labeling of biomolecules with a radionuclide is a key goal in radiopharmaceutical development. This study explores two different ligand systems for fac-[Re(CO)3L]+ complexes, that could be used in bioconjugation. The first approach uses a tridentate ligand having a sulfonamide linkage …
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Design, synthesis, and biochemical evaluation of three types of hexestrol-based probes for estrogen receptor: Fluorine-18 radiopharmaceuticals, bivalent ligands and diazirine photoaffinity reagents
… carcinoma. Molecular probes, such as fluorine-18 radiopharmaceuticals, bivalent ligands, and affinity labels, provide information toward a better understanding of ER localization, structure, and function. We have prepared two fluorinated analogs of 2-oxohexestrol as potential diagnostic imaging …
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Development of Fluorine-18 Halofluorination and Fluorine-18 Fluoride Ion Displacement Reactions for the Synthesis of Fluorine-18 Labeled Radiopharmaceuticals (Spiperone, Spiroperidol, N-Alkylation, Radioactivity)
Two fluorine-18 labeling methods, ('18)F halofluorination and ('18)F fluoride ion displacement reactions, have been developed to assess their potential for labeling molecules with the positron-emitting radionuclide fluorine-18 at the no-carrier-added level.
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Evaluation of PBR in Breast Cancer
… for PBR, and compares the radioligands to radiopharmaceuticals that map metabolism: FDG) and proliferation: 3'-[18F]fluoro-L-thymidine, FLT). The research has two specific aims: 1) to compare PBR expression with measures of cellular proliferation and aggression; 2) to directly compare …
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Structually diverse Cu-64-labeled RGD peptide conjugates for PET imaging of αvβ3 expression
… peptides have emerged as an important class of radiopharmaceuticals for diagnostic imaging and cancer therapy. Following radionuclide labeling, the specific receptor-binding properties of the ligand can be exploited to guide the radioactivity to tissues expressing a particular receptor. This …
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Development of Radiochemical Quality Control Methods for Ra-223 and Th-227 Radiotherapies
… mainstay of patient management. The majority of radiopharmaceuticals deployed to date undergo a single radioactive transition (decay) to reach a stable ground state. Complex emitters, which produce a series of daughter radionuclides, are emerging as novel radiopharmaceuticals, and there is a need …
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Exploring the binding of amine and sulfonamide ligands in Rhenium(I) Tricarbonyl and Platinum(II) complexes
… with decreasing distance to Pt. Metal nuclide radiopharmaceuticals contain a metal core and an inner ligating unit, usually having chelate rings. The development of the advantageous fac-[<sup>99m</sup>Tc(CO)<sub>3</sub>(H<sub>2</sub>O)<sub>3</sub>]<sup>+</sup> precursor has opened new …
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Design, Synthesis and Biological Properties of Estrogen Receptor Binding Breast Tumor Localizing Agents
… for usefulness as estrogen receptor binding radiopharmaceuticals. Two of these compounds, 16(alpha)-bromoestradiol-17(beta) and 11(beta)-methoxy-16(alpha)-bromoestradiol-17(beta) exhibited high binding affinity for the estrogen receptor, and were predicted to exhibit high binding selectivity …
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