Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 41 for “"Radiopharmaceutical"”.
-
Comparison of selected radiopharmaceutical chromatographic quality control procedures
<p>The purpose of this study was to compare the accuracy and reproducibility of two commercially available chromatography kits with Instant Thin Layer Chromatography-Silica Gel (ITLC-SG) and Whatman Chromatography Paper. The two commercial kits evaluated were the- MAC Klt- produced-General …
-
Fabrication of a novel radiopharmaceutical: lutetium-177 loaded MCM-41mesoporous silica
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Targeted therapy of cancer, by binding the radionuclide with a carrier agent, provides more accurate delivery to focal tumor cell with low uptake in normal organs. In this paper, a new radio-loaded nanoparticle has been …
-
Production and separation of medically relevant terbium-161 for radiopharmaceutical applications and recycling of target materials
The development of effective production and purification methods for terbium-161 (161Tb) is crucial for advancing targeted radionuclide therapy applications in nuclear medicine. Here, we present two approaches for the production and purification of 161Tb using high-flux neutron irradiation and …
-
Room temperature semiconductor detector performance enhancement for multi-energy spect imaging system development and its application in alpha emitter radiopharmaceutical therapy
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01
-
Comprehensive integration of safety, optimization, and regulation in ¹⁷⁷Lu-based theranostic radiopharmaceuticals: from production to dose assessment
… regulations, and internal dose assessment in radiopharmaceutical clinical applications. The study reviews regulations for obtaining a license from the Canadian Nuclear Safety Commission for a radiopharmaceutical therapy facility. It also examines internal dose assessment in nuclear medicine, …
-
Planar visual fusion scintigraphy
… useful information about the distribution of the radiopharmaceutical being used, often does not provide adequate information about the surrounding anatomical structures. A proposed method to solve this problem is by registering and fusing a scintigraphic image with a digital visual image. Fusing …
-
Complexation of trivalent lanthanides by three diphosphonate ligands in the blood plasma
… thought to improve the therapeutic effect of the radiopharmaceutical. However, ¹⁶⁶HoEDTMP is not an effective pain palliation agent and consequently the search for a more effective bone cancer therapeutic radiopharmaceutical involving ¹⁶⁶Ho continues. A ligand is being sought which complexes …
-
The use of lymphoscintigraphy to localise the sentinel lymph node
… debate centres on whether to use a blue dye or radiopharmaceutical method either singly or in combination.
-
Development of a new portable instrument for in-situ activity measurement of Radionuclides in Nuclear Medicine
… for example it is laborious to standardize 11C radiopharmaceutical solution by sending this solution form Cannizzaro hospital in Catania to ENEA-INMRI in Rome. For that reason, it is important to have a portable instrument to standardize short half-live radionuclide inside radiopharmaceuticals …
-
Evaluation of PBR in Breast Cancer
… PET) in the detection of cancer began with the radiopharmaceutical 2-[18F]fluoro-2-deoxyglucose: FDG) used for measuring altered cellular metabolism. Specific radioligands are being developed to allow non-invasive analysis of protein expression to further characterize tumors. One protein that …
-
Numerical modelling of dilatant rock joints
… complex was studied in order to assess its radiopharmaceutical usefulness. The major analytical techniques used in this study are potentiometry and high resolution nuclear magnetic resonance spectroscopy.
-
Imaging Prostate Cancer: Design, Synthesis, and in Vivo Testing of Steroidal and Non-Steroidal Androgen Selective PET Radiopharmaceuticals
… in hope to elucidate the role that SHBG plays in radiopharmaceutical delivery.
-
Copper-64 radiopharmaceuticals for receptor-mediated tumor imaging and radiotherapy
… agent will require further experimentation. This radiopharmaceutical showed promising initial results in a biodistribution study in male Lewis rats, however, it should be compared to 111In-DOTA-sst2-ANT in the same model. Nuclear localization of copper-64 from two somatostatin analogues differing …
-
Synthesis of Functional Analogs of Non-Steroidal Estrogens
… the aim of developing an estrogen receptor-based radiopharmaceutical, two new iodinated estrogens, 1-(2'-iodo-4'-hydroxyphenyl)-2-(4'-hydroxyphenyl)butane and erythro-3-(2'-iodo-4'-hydroxyphenyl)-4-(4'-hydroxyphenyl)hexane (2'-iodohexestrol), were prepared. The relative binding affinities of these …
-
Requirements for the detection of atherosclerosis lesions in carotid arteries with SPECT
… imaging. Several researchers are developing radiopharmaceuticals for atherosclerosis imaging. In this thesis, we provided procedural guidelines to detect carotid lesions with single photon ,Emission Computed Tomography (SPECT). We first established a method to assess the requirements for …
-
In vitro comparison of methylene diphosphonate radiopharmaceuticals
<p>The radiopharmaceutical methylene diphosphonate (MDP) is a relatively new diagnostic tool and currently in widespread use as a gone imaging agent to delineate areas of altered osteogenesis. MDP is chelated with radioactive technetium-99m (Tc99m) and injected into the venous system of the body. …
-
Choosing transportation alternatives for highly perishable goods
… and costs involved in shipping highly perishable radiopharmaceuticals. The first stage of the study describes aspects of THC's radiopharmaceutical supply chain from order taking at the manufacturing plant to distribution of the prepared doses at the radiopharmacies. The second stage establishes …
-
Development of a Mathematical Model of Renal Function for Clinical Application
… monitoring OIH tagged with 1-131 as the radiopharmaceutical passes through each compartment. Time/ activity curves are plotted for the data and used as inputs to the model parameter estimation routine. The compartments are described by a set of first order ordinary differential equations …
-
Targeting the bombesin subtype 2 receptor for the diagnosis and treatment of metastatic prostate cancer
… promising method for diagnostic and therapeutic radiopharmaceutical development for metastatic prostate cancer. The results of this research demonstrate the potential diagnostic capabilities of BB2r targeted compounds. We also demonstrate a potential mechanism of therapeutic effect while …
-
The Synthesis and Characterization Of A Functionalized Diethylenetriamine Rhenium Complex Followed By Analytical Analysis of Novel Rhenium-Luteinizing Hormone-Releasing Hormone Conjugates
… use of technetium-99m (99mTc) in over 85% of radiopharmaceutical compounds, it is an ideal candidate for generating medically relevant organometallic complexes. The [99mTc(CO)3L]+ core, when facially chelated by tridentate ligands, shows superior pharmacokinetics and stability. Given the …
Page 1 of 3