Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"Radiolabelling"”.
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Synthesis, radiolabelling and pharmacological evaluation of CO-releasing molecules
… likely due to the difference in counterion. Radiolabelling of the multimeric ligands was unsuccessful.
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Generation of Glioblastoma specific SNAP based antibody fusion proteins for future radiolabelling application
Each year, Central Nervous System (CNS) cancers affect about 300,000 individuals globally, accounting for 1-2% of all adult cancer cases. Despite being rare, CNS cancers reportedly have disproportionately high morbidity and mortality rates compared to their incidence. Globally, Glioblastoma …
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New technique for radiolabelling tracer with 64CU for positron emission particles tracking (PEPT) experiments
… in this thesis was to develop a technique for radiolabelling tracers with 64Cu, and to test their efficacy in PEPT experiment. The work was conducted at Radionuclide Production Department, iThemba LABS near Cape Town, where high purity 64Cu was obtained by a two stages separation method using …
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Improving the selectivity of the radio-labelling of ion exchange resin tracers for positron emission particle tracking
… a purification technique into a "standard" radiolabelling method used at iThemba LABS. A small 0.5 ml Amberchrom CG-71 column is loaded with the ⁶⁸Ga generator eluent in 7 M HCl, then rinsed of most the contaminants before eluting the product with distilled water and used in the …
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Design and evaluation of novel PET and SPECT tracers for imaging the monoamine system and the P-gp transporter
… is reported. In a following section, the radiolabelling as well as the in vivo characterization of two [11C]-labelled pyrrole-2-carboxamide derivatives are described. In vitro, they were both potent inhibitors of monoamine oxidase-A. The synthesis along with the radiolabelling and in vivo …
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Development of 18F radiochemistry for positron emission particle tracking (PEPT)
… trifluoroacetic acid (TFA) complex, and used for radiolabelling. The anion exchange resins Purolite A870 and A200 were investigated for their ability to exchange non-radioactive counter ions for the required species. Ion exchange techniques were used to label small phase-representative tracer …
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Small scale manufacturing and scintigraphic detection of pellet formulations
This research was designed to develop radiolabelling methods for pellets or mini-tablets so that their in vivo behaviour can be assessed using gamma scintigraphy. Eight different pellet formulation profiles were developed using paracetamol and indomethacin as partially and poorly water soluble …
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Imaging Biomarkers of Response to Immune Checkpoint Inhibition in Melanoma
… inhibitors. Magnetic resonance imaging (MRI), radiolabelling of neutrophils for single-photon emission computed tomography (SPECT) imaging and intravital imaging are explored as part of a co-clinical study on metastatic melanoma patients and syngeneic mouse models of cancer immunotherapy.
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Verfahren zur Funktionalisierung und bioaktiven Ausrüstung von Implantatoberflächen für eine verbesserte Gewebeintegration
… peptide. Immobilised amounts were analysed via radiolabelling and ELISA (insulin). Covalent immobilisation onto amino-ppx was proven by surface-MALDI-TOF-MS. Radiolabelling and ELISA experiments with fibrinogen indicated a very low protein adsorption on CM-dextran-modified surfaces. In vitro …
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The transduction of light signals controlling floral induction in Pharbitis nil
… nil cotyledons (the inductive organs) by radiolabelling with [32P]-orthophosphate and subsequent separation of the aqueous components by HPLC and the lipid components by TLC, and comparison with authentic standards. However, radiolabelling did not permit identification of any light …
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Liposomes as carriers for polymyxins in the treatment of cystic fibrosis lung infections
… liposomal polymyxin B, analytical methodology (radiolabelling, HPLC and protein assay) applicable to liposomal formulations was established. Liposomes were prepared by the dehydration-rehydration method and encapsulation efficiencies were determined for a number of phospholipid compositions. …
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Fructose and the Maillard reaction
… A. J. 1992, Clin. Chem. X8,1301-1303). In vitro radiolabelling illustrates that incorporation of fructose into protein, through the Maillard reaction, is more swift than glucose. The development of AGE-fluorescence reflects the incorporation of the two sugars, i. e. higher upon fructation. A …
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Microbial Degradation of Acetaldehyde in Freshwater, Estuarine and Marine Environments
… carbon is conserved for growth. Using 14C-radiolabelling, rates of microbial dissimilation were shown to be significantly higher than assimilation rates in the freshwater rivers, estuaries, and coastal seas of south-west England, with summer rates significantly higher than winter. These …
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Biochemical and immunological investigations into cystic fibrosis
… by immunoprecipitation, immunofluorescent and radiolabelling techniques. Immunoprecipitation and immunofluorescence showed that, after absorption, the antisera produced from fibroblast medium had specificity for CF samples. Sadiolabelling experiments indicated that the absorbed antisera …
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Synthesis, Characterization, and Evaluation of Novel BODIPY Dyes With Theranostic Applications
… PET, and SPECT imaging. The exploration of radiolabelling highly functionalized long wavelength BODIPYs is detailed herein. Chapter 5 conveys an effective method towards the preparation of carborane-appended BODIPYs for boron neutron capture therapy. The use of highly efficient …
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An analysis of the outer membrane of desulfovibrio vulgaris (Woolwich)
… of cells adhering to mild steel coupons. Fe-radiolabelling of OM components immobilised on nitrocellulose shows that Omps 1, 2 & 3 bind Fe(II). Blocking experiments using copper & magnesium indicate Omp1 to be Fe(II) specific while Omps 2 3 are not. The enhancement of Omp2 observed in C-Fe NC …
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Strategies for structural studies of poly(ADP-ribose) glycohydrolase: Towards the validation of a novel therapeutic target
… and precision were compared to a widely-used radiolabelling assay. Second, several expression and purification systems were constructed in order to obtain high quantities of soluble human PARG protein adequate for in vitrostructural studies. The efficacy of these strategies was demonstrated in …
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