Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Radioiodine"”.
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BISMUTH-FUNCTIONALIZED SORBENTS FOR RADIOIODINE CAPTURE
The soybean oil was used as a porogen to tailor porestructure of gels made with tetraethoxysilane (TEOS) and TEOS + methyltrimethoxysilane (MTMS) silica precursor. Oil concentrations of 9.09 v/v% and 33.33 v/v% were studied. The miscibility of the oil and precursor decreased as the silica gel …
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Investigation of a novel modified fixed dose determination protocol for radioiodine treatment of feline hyperthyroidism
Background: Radioiodine is the treatment of choice for feline hyperthyroidism. The ideal method of dose determination of 131I remains controversial. Objective: To compare a method of radioiodine dose determination that utilized thyroid scintigraphy with a standard fixed dose for treatment of feline …
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Significance of Salivary Gland Radioiodine Retention on Post-ablation 131I Scintigraphy as a Predictor of Salivary Gland Dysfunction in Patients with Differentiated Thyroid Carcinoma
… functional changes in salivary glands after radioiodine therapy. METHODS: We evaluated 90 patients who received initial high-dose (≥3.7 GBq) radioiodine therapy after totalthyroidectomy.Allpatients underwent diagnostic (DWS) and post-ablation (TWS) 131I whole-body scintigraphy. Visual …
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Efficacy of single fixed dose of radioiodine (I-131) therapy in patients with hyperthyroidism at Groote Schuur Hospital
… FT4 (12-51 mmol/L) (p=0.002). We administered a radioiodine therapy dose of 456.6±54.8 MBq (Mean ± SD) to these 409 patients. Among the 353 patients, with complete records, 314(89%) achieved cure at some stage after receiving one dose of RAI; 239(76%) achieving cure ≤ 6 months of therapy and …
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Leveraging copper chelators as targeted therapy for BRAFV600E mutant thyroid cancer
… treated effectively with surgical resection and radioiodine therapy, survival drops precipitously in metastatic or radioiodine-resistant disease. 60% of papillary thyroid cancers (PTC) have an oncogenic V600E mutation in the kinase BRAF, which leads to a constitutively active and oncogenic …
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In vitro evaluation of cytotoxicity and cellular uptake of alternating copolymers for use as drug delivery vehicles
… imaging), fluorescent dyes (NIRF imaging), and radioiodine (nuclear imaging and radioimmunotherapy) to the backbone. Attachment of hydrocarbon or perfluorocarbon sidechains provides amphiphilicity to produce the multimodal self-assembling micelles. Additionally, encapsulation procedures for …
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Use of a quartz crystal microbalance to investigate the mechanical stability of silica xerogel membranes for volatile iodine capture
… on silica-based sorbents for the capture of radioiodine off-gassed during the processing of legacy waste or the reprocessing of nuclear waste. While studies investigate their iodine capture efficiency, only limited information about their mechanical applicability is found in the literature. …
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Development of alternating amphiphilic copolymers for targeted delivery applications in cancer
… backbone polymer synthesis, (2) attachment of radioiodine, and (3) targeted delivery in vitro and in vivo. The first step in the production of the alternating amphiphilic copolymers is a chemo-enzymatic condensation polymerization of polyethylene glycol (PEG) and dimethyl 5-hydroxyisophthalate …
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Evaluation of hemostasis in hyperthyroid cats
… differences of altered hemostasis resolved after radioiodine therapy, but further studies are warranted to determine if hypercoagulable state resolves.
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FROM NUCLEUS TO MITOCHONDRIA: INSIGHTS INTO THE ROLE OF TERT IN THE PROGRESSION OF PAPILLARY THYROID CARCINOMA
… can dedifferentiate and become more resistant to radioiodine used as a first-line treatment in cases of metastatic PTCs, a trait often found in TERT promoter mutated cases, significantly reducing survival rates. In this work we aimed to study the role of TERT extra-nuclear localization in the …
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SODIUM/IODIDE SYMPORTER-NIS Abundant and Important in Gastric Mucosa
… and bile ducts all express NIS, which might make radioiodine an aid in treatment and diagnosis of these cancer types.
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Evaluation of Thyroid to Background Ratios in Hyperthyroid Cats
Hyperthyroidism is the most common feline endocrinopathy. 131I is the treatment of choice, and over 50,000 cats have been treated using an empirical fixed dose. Better treatment responses could be achieved by tailoring the dose based on the severity of disease. Scintigraphy is the best method to …
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Leveraging Bio-Inspired Molecules for Cancer Theranostics
… the development of tools for enzyme-responsive radioiodine-based tumor imaging.</p> <p>Antibodies also provide a widely used and very effective platform for the delivery of a radioisotope to cancer cells. Site-specifically modified radioimmunoconjugates exhibit superior <em>in vitro</em> and …
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Einfluss der thyreostatischen Therapie auf den Erfolg einer Radioiod-Ersttherapie bei der Autoimmunthyreopathie vom Typ M. Basedow
Ziel vorliegender Studie war die Einflussfaktoren der Radioiodtherapie bei der Autoimmunthyreopathie vom Typ M. Basedow insbesondere im Hinblick auf die prätherapeutische thyreostatische Therapie aufgrund der unklaren Datenlage zu erfassen. Der Einfluss von Geschlecht, Alter, Schilddrüsenvolumen, …
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Orale versus intravenöse Radioiodtherapie bei Unifokaler Autonomie und Morbus Basedow
Im Rahmen der dieser Arbeit zugrunde liegenden prospektiven, randomisierten Studie wurden im Zeitraum Juli 2001 bis August 2002 insgesamt 120 Patienten der Klinik und Poliklinik für Nuklearmedizin der Universität Würzburg mit den Diagnosen Unifokale Autonomie (UFA) und Morbus Basedow (MB) mit einer …
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Ein effektiver und verlässlicher Ansatz zur Reduktion der Strahlenexposition des medizinischen Personals im Kontext der Radiojodtherapie
Die Validierung der Aktivität der Jod-131-Kapseln vor der Radiojodtherapie ist gesetzlich vorgeschrieben. Die Anwendung des dargestellten alternativen Messverfahrens führt zu einer erheblichen Reduktion der Strahlenbelastung des medizinischen Personals und insbesondere der Hände. Es ermöglicht eine …