Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Radiobiology"”.
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Ion dosimetry for radiobiology experiments employing laser-accelerated beams
… second experimental chapter presents two radiobiology experiments where cells are exposed to laser-accelerated particles. The dose delivered was measured using RCF, which was calibrated in previous experimental campaigns. CR39, a separate dosimeter, was also utilized in these experiments, …
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Radiobiology of normal rat lung in Boron Neutron Capture Therapy
… effectiveness. This project investigated the radiobiology of normal rat lung in BNCT and measured the relative biological effectiveness factors for the lung. Rat thorax irradiations were carried out with x-rays and neutrons with or without the boron compound boronophenylalanine-fructose …
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“Acid-spike” effect in spurs/tracks of the low/high linear energy transfer radiolysis of water : potential implications for radiobiology and nuclear industry
… the potential implications of this effect for radiobiology, some of which are briefly evoked. Our calculations were then extended to examine the effect of temperature from 25 to 350 °C on the yield of H3O+ ions that are formed in spurs of the low-LET radiolysis of water. The results showed an …
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A study of the response of the root meristem of maize to acute doses of ionizing radiations
At the commencement of any studies in radiobiology it is necessary to decide on a suitable system for investigation, either animal or plant.
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HIGH FIELD MAGNETIC RESONANCE IMAGING-BASED GEL DOSIMETRY FOR SMALL RADIATION FIELDS
… as well as for cellular and preclinical radiobiology studies (very small fields, <1 mm diameter). Radiation dose characteristics for these small fields are difficult to determine in multiple dimensions because of steep dose gradients (30-40% per mm) and conditions of electronic …
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The Stopping of Energetic Si, P and S Ions in Ni, Cu, Ge and GaAs Targets
… (IBA). These values are also of interest in radiobiology and radiotherapy, and in ion- implantation technology where shrinking feature sizes puts high demands on the accuracy of range calculations. A theory that predicts stopping powers and ranges for all projectile-target combinations is …
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Dosimetry calibration for low-energy protons produced in the ECU accelerator laboratory
… foundation for current and future proton-based radiobiology studies at ECU.
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The neutron sensitivities of Geiger-Müller counters
… when neutron beams are used for radiotherapy and radiobiology. Since gamma ray dosimeters almost always also respond to neutrons, it is generally not possible to use two different devices to measure the separate dose components. The separate doses are usually determined by making measurements with …
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Advancing Radiotherapy Treatment Through Artificial Intelligence-Driven Approaches
… is challenging, and precise quantification of radiobiology is urgently needed. To address these above limitations and needs, this dissertation aims to develop artificial intelligence (AI)-driven techniques to advance current radiotherapy treatment. Recent breakthroughs in AI, including …
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Predicting the severity of radiation skin reactions in women with breast cancer
… the study was based on two bodies of knowledge, radiobiology and wound healing. This framework specified three sets of potential predictors of radiation induced skin reactions. These were radiation factors (e.g. dose, fractionation), genetic factors (e.g. personal and family history or cancer, …
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Analysis of radiosensitivity in South African cervical and breast cancer patients
… and the γ-H2AX assay are two assays used in radiobiology to study DNA DSB and repair. Breast cancer is the leading cancer amongst South African women, with a lifetime risk of 1 in 34. Since most cancer patients in South Africa present with late-stage disease, chemotherapy and radiotherapy are …
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Experimental measurements and Monte Carlo simulations of a transport beamline for laser-driven proton beams
… Therefore, to reach the required accuracy for radiobiology experiments, it is desirable to better handle and control the transported beam. According to this requirement, new prototypes for the beam transport and handling have been designed and realised at INFN-LNS in Catania. They can be …
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A Monte Carlo-based Model Of Gold Nanoparticle Radiosensitization
The goal of radiotherapy is to operate within the therapeutic window - delivering doses of ionizing radiation to achieve locoregional tumour control, while minimizing normal tissue toxicity. A greater therapeutic ratio can be achieved by utilizing radiosensitizing agents designed to enhance the …
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Challenging the Rigor of Alpha/Beta and Relative Biological Effectiveness in Tumor Contorl [sic] Probability Determinations via In Silico Modeling That Incorporates Individualized Biological and Physiological Data
BACKGROUND: Current methods for predicting the response of tumors to radiation therapy focus largely on linear quadratic (LQ) model survival parameters generated from conventional radiotherapy regimens, of ~2 Gy/fraction. The accuracy of the LQ model has been questioned for high dose per fraction …
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Pre-clinical evaluation of lethal and sublethal DNA damage in human cell cultures by ultrashort pulse and ultra-high dose rate laser accelerated protons
Particle therapy has been cited as an effective treatment modality, compared to photons and electrons-based therapies for solid tumors located in close proximity to critical organs, such as spinal cord, brain and heart. Numerous studies have demonstrated the feasibility of using high LET particles …
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ATM-Dependent ERK Signaling in Response to DNA Double Strand Breaks
Ionizing radiation (IR) triggers many signaling pathways stemming from DNA damage, and, independently, from extra-nuclear events. To generate radio-mimetic DNA double-strand breaks (DSBs) without and minimizing the effects on extra-nuclear radiation targets, human (p53+) glioma and carcinoma cells …
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An in vitro investigation of the impact of radiation induced bystander effect on the therapeutic irradiation of a prostate cancer cell line.
… In the last decade the fundamental dogma of radiobiology, known as the ‘target theory’, has been reviewed. The extensive experimental evidence demonstrates that not only cell nucleus but also cellular cytoplasm, membrane, and even neighbouring cells, located outside the radiation field, …
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Analysis of Minocycline as a Radioprotectant
<p>Exposure to radiation is increasing in a variety of settings including space exploration, diagnostic medical procedures and radiotherapy. Cells of the hematopoietic system, such as white blood cells (WBC), are especially sensitive to radiation and their decline can result in Acute Radiation …