Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Radio-protection"”.
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The role of c-FLIP in regulating resistance to ionizing radiation
Resistance to radiotherapy is a significant cause of treatment failure and tumour relapse. Therefore, strategies to improve the efficiency of cell death induction by ionizing radiation (IR) are required to improve therapeutic outcomes. FLIP, anendogenous caspase-8 inhibitor is a critical regulator …
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Activation of developmental signaling pathways in hematopoietic stem cell regeneration
… To determine if Notch gain of function provides radio-protection we infected stem cells with an active form of Notch prior to radiation and then scored self renewal potential in vitro. This led us to the conclusion that Notch gain of function can provide a self renewal benefit to irradiated …
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Novel Synthetic Compound, KR-22332, has radio-protective effect through inhibition of Mitochondrial Dysfunction and ROS Generation
… is observed almost all patients. Several radio-protective agents are developed but there is no definite agent to prevent. We found novel synthetic compound 3-Amino-3-(4-fluoto-phenyl)-1H-quinoliune-2,4-dione (KR-22332) as an candidate of radio-protective agent and the aim of this study is …