Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Radicicol"”.
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Identification and Characterization of Novel Mycotoxin Degrading Enzymes
… acid lactones beyond zearalenone, including radicicol. Radicicol inhibits the activity of Heat Shock Protein 90, however following enzymatic treatment, this activity was significantly attenuated. Identifying mycotoxin degradation activity supports continued agricultural production while …
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Studies towards a fast and efficient total synthesis of LL-Z1640-2
… lactones such as 7-oxo-zeaenol, zeaenol and radicicol. Although there has been a significant amount of work dedicated to the synthesis of radicicol, the efforts towards LLZ1640-2 have been rather limited. At the outset of the research contained within this thesis, only two total syntheses of …
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"Clostridium botulinum" C2-Toxin: Interaktion der Toxinkomponenten und Translokation der Enzymkomponente in das Zytosol von Zielzellen
… zellgängigen Hsp90-Inhibitoren Geldanamycin und Radicicol gezeigt. Geldanamycin und Radicicol verzögerten die Vergiftung von Vero-Zellen durch C2-Toxin und schützten das zelluläre Aktin vor ADP-Ribosylierung. Die Inhibitoren hatten keinen Einfluss auf die ADP-Ribosylierung von Aktin in vitro. Sie …
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Evaluating the Therapeutic Effect of an Hsp90 Inhibitor in Mouse Models of Alzheimer’s Disease
… with favorable CNS-permeability. OS47720, a radicicol derivative Hsp90 inhibitor, produced comparable effects to those of 17- AAG in inducing heat shock-like responses and promoting synaptic protein expression. Electrophysiology studies on coherence demonstrated enhancement of neuronal …
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The Cystic Fibrosis Transmembrane Conductance Regulator: Regulation by HSP-90
<p>The hypothesis of this project is that a functionally relevant association exists between CFTR and Hsp90. In testing this hypothesis, (a) the association of CFTR and Hsp90 is confirmed via crosslinking and immunoprecipitation of CFTR from stably transfected HEK-293 cells, electrophoretic …