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Showing 1 to 4 of 4 for “"Radical Sam Enzyme"”.
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Sensitivity of Radical SAM Enzyme MftC to Molecular Oxygen
<p>MftC is a radical S-adenosyl L-methionine (SAM) enzyme that catalyzes the first step in the production of mycofactocin. It is a ribosomally synthesized post-translationally modified (RiPP) redox cofactor shown to be essential for the survival of bacteria in the <em>Mycobacterium</em> genus in …
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Untersuchungen zur Biosynthese und Regulation von Oligosaccharid-Antibiotika
… Die Inaktivierung führte jeweils zum Zusammenbruch der Avilamycin-Biosynthese. Bei der Überexpression von aviC1 im Wildtyp wurde die Avilamycin-Biosynthese um das 4,6-fache gesteigert, bei gleichzeitiger Überexpression beider Regulatoren stieg die Avilamycin-Biosynthese um das 4,8-fache. …
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Chemical Modification of Iron-Sulfur Cofactors
… the electronic-structure studies of FeS enzymes. In Chapter 1, selected examples of Fe–S enzymes, their chemistry, and their remaining mechanistic questions are described in addition to the discussion on advantages and limitations of ⁵⁷Fe-specific techniques. In Chapter 2, we demonstrate …
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Investigation of radical SAM-mediated thioether installation in RiPP natural products
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-05-01