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Showing 1 to 5 of 5 for “"Radical SAM Enzymes"”.
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Biochemical and structural characterization of radical SAM enzymes Elp3 and viperin
Made available in DSpace on 2017-03-01T17:00:49Z (GMT). No. of bitstreams: 2 SELVADURAI-DISSERTATION-2016.pdf: 4094456 bytes, checksum: 0f8ac9e151d2ca2bcc0b86f28ca3e24e (MD5) LICENSE.txt: 4217 bytes, checksum: 97822b5b33afa06a1dd64bba5cddd611 (MD5) Previous issue date: 2016-08-19
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Biochemical and structural characterization of radical SAM enzymes Elp3 and viperin
The radical SAM (S-adenosylmethionine) superfamily consists of a diverse set of enzymes which use [4Fe-4S] and SAM to initiate radical transformations. These diverse enzymes undergo a common series of steps where SAM is cleaved to yield methionine and a 5’-deoxyadenosyl radical intermediate …
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A Bioinformatics Approach to Identifying Radical SAM (S-Adenosyl-L-Methionine) Enzymes
Radical SAM enzymes are ancient, essential enzymes. They perform radical chemical reactions in virtually all living organisms and are involved in producing antibiotics, generating greenhouse gases, human health, and likely many other essential roles that have yet to be established. A wide variety …
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Organometallic Chemistry in Fe–S Clusters
… be important intermediates in several classes of enzymes, including radical S-adenosyl-L-methionine (SAM) enzymes and enzymes involved in terpene biosynthesis. Due to the transient nature of these intermediates, full characterization of the geometric and electronic structures of enzymatic …
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Biosynthetic and bioinformatic investigation of RiPPs with radical SAM-installed crosslinks
… to the emerging antimicrobial resistance crisis. Radical S-adenosylmethionine enzymes (rSAM) are responsible for producing intriguing and complex molecules, some of which are antibiotics. These enzymes have been demonstrated to catalyze C-C, C-S, C-O-C, and C-N crosslink formation among other …