Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Radiation sensitivity"”.
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Enhancing Radiation Sensitivity In Non-Small Cell Lung Cancer
… the leading cause of cancer-related death. While radiation therapy is one of the standard treatments for lung cancer, the disease outcome after radiotherapy is still far from satisfactory despite ongoing advances in radiation techniques. Enhancing the radiosensitivity of lung cancer has the …
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THE EFFECT OF SILENCING THE WILMS' TUMOR 1 GENE ON THE RADIATION SENSITIVITY OF GLIOBLASTOMA CELLS
… genes have been implicated in resistance to radiation. To determine the role of WT1 in radiation resistance, two glioblastoma cell lines expressing WT1 were treated with siRNAs to silence this gene. Confirmation of WT1 knockdown was achieved through real-time PCR and Western blot. After …
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Personalised Risk Assessment of Low-dose Radiation Effects on Spermatogenesis
… effects of long-term, low-dose environmental radiation exposure and contamination. From the point of view of radiation microdosimetry, the energy deposition of radiation from low-dose exposure (such as from environmental radiation) is localised along its track, resulting in a non-uniform …
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Investigating The Role of Cholesterol Metabolism and Synthesis In Metastasis and Radiation Response In Aggressive Subtypes of Breast Cancer
… and also statins can improve the response to radiation in vitro. Furthermore, statins have been shown to target the cells with stem like-properties called cancer stem cells (CSCs) which are known to be important in the pathogenesis of aggressive breast cancers. However, the effects of statins …
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Role of Cell Death Regulatory Genes and Radiation Response in Pancreatic Adenocarcinomas
… and TGF-P signalling, and this caused enhanced sensitivity of cell lines to radiation. The restoration of RH function by FrI was linked to down-modulation of DNA methyltransferase enzyme that is often implicated in hypermethylation of promoters. Over-expression of RII in pancreatic tumour cells …
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Polymers for Next Generation Lithography
… but suffers from fundamental drawback of poor radiation sensitivity, brittle film formation and poor resistance to plasma etching, making it a bad choice for the process of lithography. This can be partially offset by functionalizing with more stable pendant groups. We have selected substituted …
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Characterizing in vitro propagation and radiation response of murine mammary stem cells
… be sensitive to known carcinogens (i.e. ionizing radiation), which impact their susceptibility to transformation. The involvement of mammary stem cells in tumorigenesis could explain the heterogeneity and molecular complexity of breast cancer. However, the involvement and the underlying mechanisms …
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Mitochondrial dynamics in the radiation response of cancer cells
… cell mitochondrial features and inherent radiosensitivity, and to determine the effect of modulation of mitochondrial dynamics on radiation response using a fission inhibitor, Mdivi-1. Methods: Mitochondrial status in a number of cancer cell lines was characterised by assessment of …
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Investigation of Radiation Injury In The Esophagus From Definitive Chemoradiation Therapy Using Novel Imaging Biomarkers
<p>Radiation injury in the esophagus occurs with high frequency from the treatment of non-small cell lung cancer (NSCLC). Radiation esophagitis is an acute normal tissue toxicity that negatively affects treatment efficacy by limiting dose and potentially interrupting radiation therapy. Clinical …
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Enhancement of Antitumor Activities of a Selective Cyclooxygenase-2 Inhibitor, Celecoxib on the Lewis Lung Carcinoma that Express Cyclooxygenase-2
… COX-2 activity is associated with the enhanced radiation sensitivity of tumors without appreciably increasing the effects of radiation on normal tissue. In this study, we experimented to know the effect of selective COX-2 inhibitor to inhibit tumor growth and pulmonary metastasis in animal …
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Effective dose enhancement using gold as a radiation sensitizer: a Monte Carlo study
… great strides have been made in improving radiation therapy, the issue of non-specific irradiation of healthy tissue still persists. One of the most promising modalities currently being explored involves using contrast material to enhance the radiation sensitivity of a tumor. Such treatment …
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The ecology and evolutionary history of the Deinococcaceae family
… capability to withstand extreme doses of gamma radiation and prolonged desiccation. D. radiodurans is also type species and the first described member of the Deinococcus genus. It demonstrates approximately 3000 times more radiation resistance capability than humans and 50 times more than …
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Dna Polymerase Θ (Polq) and The Cellular Defense Against Dna Damage
… <em>Polq</em>-null mice are hypersensitive to radiation and the peripheral blood cells of these mice display increased spontaneous and ionizing radiation-induced levels of micronuclei (a hallmark of gross chromosomal aberrations), though the mice apparently develop normally.</p> <p>Although a …
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Discoveries of Targets and Novel Agents for the Treatment of Ischemic Retinopathy and Neovascular Disease
… other ocular insults and diseases including radiation retinopathy (RR) and retinal vein occlusion. These latter cases are generally less common but, like DR and AMD, they are characterized by an initial injury, chronic inflammation, and ischemia which perpetuates episodes of retinal …
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Gamma irradiation response of photonic crystal and standard optical fibre Bragg grating sensors for radiation dosimetry
… Fibre Bragg Grating Sensors (FBGs) for Gamma Radiation Dosimetry. A comparative analysis of responses to gamma irradiation between standard commercial FBGs and new generation FBGs written in Photonic Crystal fibre (PCF) were examined under similar regimes and conditions. Current research …
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Growth and applicability of radiation-responsive silica nanowires
… such as high responsiveness towards ion irradiation. By using two materials with a relatively low surface energy (indium and silicon oxide) this is experimentally and theoretically demonstrated in this doctoral thesis. The augmentation of VLS nanowire growth with ion bombardment enables …