Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Radiation Medicine"”.
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Assessment of imaging dose from the kilovoltage cone beam computed tomography system on board the Varian Halcyon linear accelerator
… concerns about the contribution of low-energy radiation dose to the overall integral dose and possible induction of secondary primary tumours. In this study, the dose to organs and tissues located in the pelvic and thoracic regions of the body from kV CBCT imaging was estimated using the GATE …
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Efficacy of single fixed dose of radioiodine (I-131) therapy in patients with hyperthyroidism at Groote Schuur Hospital
Aim: The aims of this audit were: To determine the proportion of hyperthyroid patients receiving I-131 therapy in whom treatment with a single fixed dose was successful, as defined by the achievement of euthyroidism or hypothyroidism 6-months after the therapy; To identify patients in whom …
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Comparison of 18F-Fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (18F-FDG PET/CT) and conventional imaging (CI) for locally advanced breast cancer staging: a prospective study from a tertiary hospital cancer centre in Western Cape
Background: Breast cancer is the second most common cancer in adults and the most frequent cancer diagnosed in women. In South Africa, breast cancer accounts for 38.5% of cancers diagnosed in women. Since the presence, extent and location of distant metastases is one important prognostic factor in …
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The conclusions drawn from ventilation/perfusion single photon emission computed tomography (SPECT) compared to lung perfusion SPECT and a chest x-ray (CXR) in patients with suspected pulmonary pulmonary thromboembolism
Purpose: There are conflicting results from studies on whether the ventilation (V) scintigraphy can be safely omitted or replaced by a chest x-ray. These studies were based on planar ventilation perfusion (V/Q) scintigraphy. We evaluated the value of the V single photon emission computed tomography …
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CT angiogram findings in patients presenting with mechanical strangulation and near hanging injuries
Background: Blunt cerebrovascular injury (BCVI) is relatively uncommon in near-hanging and strangulation injuries but may have devastating neurological outcome. In developed countries, CT angiography (CTA) of the head and neck is performed as a screening tool in the acute clinical setting. This …
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Mitochondrial dynamics in the radiation response of cancer cells
… of modulation of mitochondrial dynamics on radiation response using a fission inhibitor, Mdivi-1. Methods: Mitochondrial status in a number of cancer cell lines was characterised by assessment of mitochondrial morphology, respiration and membrane potential using MitoTracker® Red staining, …
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The Safe and Effective Clinical Deployment of Artificial Intelligence to ols
… half of these patients will be treated with radiation therapy, a complex technique that requires an interdisciplinary team of clinical staff and expensive equipment to be delivered safely. Cancer centers in Low- and Middle-Income Countries (LMIC) have an especially difficult time meeting the …
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Quantifying The Magnitude of to tal Dose Deviation Caused By Various Sources of Error Among Iroc Phantom Irradiation Results
<p>The Imaging and Radiation Oncology Core (IROC) phantoms are used as an end-to-end test of an institution’s radiotherapy processes, and for clinical trial credentialing. Phantoms are treated like patients, and evaluation of the doses received by the thermoluminescent dosimeters (TLDs) inside the …
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Automated Radiotherapy Treatment Planning for Breast Cancer: A Robust to ol for Global Deployment
… and mortality. However, a growing shortage of radiation staff worldwide threatens the prompt delivery of these treatments.This thesis proposes an automated solution to address the limited accessibility of radiotherapy planning in breast cancer management by developing an end-to-end automated …
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Development of Lineal Energy Spectrum-Based Biological Effects Models for Protons
… U87, and AGO cell lines following proton irradiation, mathematical models describing the relative biological effectiveness of proton therapy as a function of lineal energy and linear energy transfer were developed. It was determined that the potential benefits of lineal energy spectrum-based …
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Fasting Reduces Intestinal Radiotoxicity Enabling Dose-Escalated Radiotherapy For Pancreatic Cancer
… the intestine from the toxic side-effects of radiation may enable dose-escalation that could achieve more effective local control of disease. We and others have previously shown that a fast of 24 hours protects mice from lethal doses of the DNA-damaging agent etoposide. In this study, we …
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A Preclinical Model of Ionizing Radiation and TNF-alpha Gene Therapy for Cancer
… (TNF-α) could enhance the effect of ionizing radiation in an aggressive, rapidly growing glioma tumor (C6) model. Plasmid DNA is an attractive vector system for delivery of foreign genes into eukaryotic cells due to its advantages including low immunogenicity <em>in vivo</em>, lesser toxicity …
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CBCT Perceptions of Radiology Leaders in the Midwest Dental Schools: A Qualitative Study
<p>Problem</p> <p>The integration of Cone Beam Computed Tomography (CBCT) in dental education is hindered by a lack of formal training among radiology leaders, insufficient institutional support, and financial constraints. Despite the proven efficacy of CBCT in enhancing diagnostic accuracy and …
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Auto-Segmentation In Pancreatic and Liver Radiation Therapy
… regimens, such as stereotactic body radiation therapy (SBRT), are emerging as an important pillar of the management of liver and pancreatic cancer. The success of these treatment modalities hinges upon the precise and standardized segmentation of organs-at-risk and target volumes to …
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Development of A Remote Dosimetric Audit Framework For Carbon Therapy
… for carbon ion therapy.</p> <p>The Imaging and Radiation Oncology Core (IROC) conducts remote audits of photon and proton therapy. These audits are used to ensure comparability and consistency among radiotherapy clinics and are an important peer-review tool to ensure accurate dose delivery. The …
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The Development of Artificial Intelligence-Based to ols For Expert Peer Review of Radiotherapy Treatment Plans
<p>Creating a patient-specific radiation treatment plan is a time-consuming and operator-dependent manual process. The treatment planner adjusts the planning parameters in a trial-and-error fashion in an effort to balance the competing clinical objectives of tumor coverage and normal tissue …
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Methods for the Prediction of Osteoradionecrosis resulting from Head and Neck Cancer Radiation Therapy
… of the primary methods to treat HNC is through radiation therapy (RT). While RT is effective at treating HNC, late toxicities resulting from treatment can occur months to years post-treatment and can cause debilitating quality of life changes for HNC survivors. One of these late toxicities is …
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Automating The Radiation Therapy Treatment Planning Process For Pediatric Patients With Medulloblastoma
… increase global access to high-quality pediatric radiation therapy by harnessing the power of artificial intelligence to automate the radiation therapy treatment planning process for pediatric patients with medulloblastoma. Radiation therapy for medulloblastoma consists of radiation to the …
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Acute Pain Prediction in Oral Cavity and Oropharyngeal Cancer Patients Receiving Radiation Therapy
… that are increasing in incidence domestically. Radiation therapy (RT) is crucial in OC/OPC management. Pain is a common and challenging symptom for most patients during therapy, as nearly all patients undergoing locoregional RT in OC/OPC require analgesia for acute iatrogenic pain. Moreover, …
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Multiparametric Magnetic Resonance Imaging Artificial Intelligence Pipeline For Oropharyngeal Cancer Radiotherapy Treatment Guidance
<p>Oropharyngeal cancer (OPC) is a widespread disease and one of the few domestic cancers that is rising in incidence. Radiographic images are crucial for assessment of OPC and aid in radiotherapy (RT) treatment. However, RT planning with conventional imaging approaches requires operator-dependent …
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