Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Radiation Insult"”.
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Role of protein kinase C isoforms in human breast tumor cell survival
… promote breast tumor cell survival following radiation treatment. This work demonstrated that depletion of PKC delta and PKC zeta isoforms from MCF-7 and MDA-MB-231 human breast tumor cells by antisense oligonucleotides significantly impaired survival following radiation insult. Antisense …
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A computer model for investigating the biomechanical effects of radiation exposure on pathological and non-pathological living human cells
The cellular response to radiation insult and studies have been carried out to investigate aspects of the cytoskeleton and the force response of the cell when probed by an AFM. Confirmed for the first time that there was a statistically significant difference for the PNT2 and PC3 cell lines in …
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Use Of Cerium Oxide Nanoparticles For Protection Against Radiation-induced Cell Death
… irradiated with a single 10 Gy dose of ionizing radiation and cell death was evaluated by propidium iodine uptake at 24 and 48 hours after radiation insult. Treatment of rat astrocytes with nanoceria resulted in an approximate 3-fold decrease in radiation induced death. These results suggest that …
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THE ROLE OF RETROTRANSPOSITION AND EXOSOMAL DNA IN RADIATION-INDUCED GENOMIC INSTABILITY
Radiation-induced genomic instability (RIGI) is characterized by an increased rate of genomic alterations including delayed mutations, chromosomal aberrations, and micronucleus formation in the descendants of irradiated cells many generations after the initial radiation insult. At present the …
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Analysis of Minocycline as a Radioprotectant
<p>Exposure to radiation is increasing in a variety of settings including space exploration, diagnostic medical procedures and radiotherapy. Cells of the hematopoietic system, such as white blood cells (WBC), are especially sensitive to radiation and their decline can result in Acute Radiation …
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Mechanisms Regulating Pulmonary Sensitivity to Radiation
… or treating pneumonitis/fibrosis following acute radiation exposure. Since it is neither ethical nor feasible to evaluate potential MCMs against radiation injury in the clinical setting, the FDA permits MCM licensure under an alternative drug development pathway ("Animal Efficacy Rule") that …