Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Rad9"”.
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HISTONE-DEPENDENT AND HISTONE-INDEPENDENT PATHWAYS FOR RAD9 CHROMATIN RECRUITMENT AND CHECKPOINT ACTIVATION
… histone H2A. Another Mec1 target is adaptor Rad9. Phosphorylation of Rad9, followed by its oligomerization, allows the recruitment and activation of the effector checkpoint kinase Rad53. This is a key step in the signal transduction cascade; it can be easily visualized as a …
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THE DNA DAMAGE CHECKPOINT REGULATES MISMATCH REPAIR COMPLEXES DURING SINGLE STRAND ANNEALING PATHWAY
… Rtt107 limits the binding of the DDC mediator Rad9/53BP1 in proximity of the DSB, reducing checkpoint signalling. We observed that the deletion of RAD9 gene rescues the defects in SSA of both rad1Δ and slx4Δ mutant cells. Therefore, we hypothesized that the DDC limits the activity of a nuclease …
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DNA damage responses in the context of the cell division cycle
… by the prototypical checkpoint protein Rad9. Here, I show that mitotic cells treated with DNA break-inducing agents activate a ‘primary’ DDR, including ATM and DNA-PK-dependent H2AX phosphorylation and recruitment of MDC1 and the MRN complex to damage sites. However, downstream DDR …
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Zur Funktion des MPH1-Gens von Saccharomyces cerevisiae bei der rekombinativen Umgehung von replikationsarretierenden DNA-Schäden
… mit den DNA damage checkpoint Mutanten rad9 und mec1 wurden gefunden. Eine Modifikation von Mph1 durch Phosphorylierung ist wahrscheinlich.Trotz der Hypostasis von mph1 zu rad51, rad52 und rad55 sind mph1 Mutanten nicht defekt in der homologen Rekombination, vielmehr zeigen sie einen …
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Saccharomyces cerevisiae DNA helicases Mph1, Srs2 and Sgs1 collaborate for the reinitiation of stalled or collapsed replication forks
… DNA-Duplexen. Deletion der Gene MEC1, RAD53, RAD9, RAD17 und RAD24, die an der Checkpoint-Antwort auf DNA-Schäden beteiligt sind, kann ebenfalls zu einer Aufhebung des synthetischen Defektes führen. Darüber hinaus ist die rad54-Deletion sub-additiv zu mph1 in Bezug auf einen spontanen …
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Replication-associated base excision repair Of oxidized bases in the mammalian genome
… DNA Ligase I as well as the stress responsive Rad9-Rad1-Hus1 (9-1-1) DNA sliding clamp. We mapped the overlapping binding sites for all of these interacting protein partners to a small disordered region near the unconserved C-terminus of NEIL1 that is dispensable for its enzymatic activity. In …
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Enzyme Architecture and Flexibility Affect DNA Topoisomerase I Function
… in isogenic yeast strains defective for the Rad9 DNA damage checkpoint, processive DNA replication, or ubiquitin-mediated proteolysis. The core and C-terminal domains are connected by extended α-helices (linker domain), which position the active site Tyr within the catalytic pocket. The …
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CDC45 Function Alters Cell Sensitivity to DNA Topoisomerase I Poisons
… a component of the DNA damage checkpoint, <em>RAD9,</em> is deleted and is synthetically lethal with another <em>tah </em>mutant <em>dpb11-10</em> at 36˚C suggesting that <em>cdc45-10</em> exhibits defects in DNA replication. To understand how Cdc45 functions to protect cells against …