Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Rad6"”.
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RAD6-abhängige DNA-Reparatur wird durch Ubiquitin- und SUMO-Modifikation von PCNA reguliert
… wird PCNA dagegen durch Komponenten des RAD6 -DNA-Reparaturwegs mono-oder multiubiquitiniert. Alle drei Modifikationen finden am gleichen,zwischen eukaryontischen Spezies kon servierten Lysin statt.Der RAD6 -DNA-Reparaturweg reguliert postreplikative DNA-Reparatur.Eine Schlüsselstellung …
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Caracterização molecular da mutação pso8-1/rad6 de Saccharomyces cerevisiae, sensível à fotoadição de psoralenos, à radiação UVC e a mutágenos químicos
… genéticos revelaram que pso8-1 é alelo ao gene RAD6. O produto do gene RAD6/UBC2 é uma enzima conjugada à ubiquitina envolvida em reparação de DNA, esporulação, recombinação, indução de mutagênese, degradação de proteínas, genes silenciosos, transposição Ty1. Enquanto o mutante pso8-1 apresenta …
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Regulación de la rutas de tolerancia a daños replicativos dependientes de RAD6, RAD5 y RAD52 durante el ciclo celular en Saccharomyces cerevisiae
… de TLS (ubiquitinación de PCNA mediada por Rad6/Rad18 y las polimerasas Rev1/Pol z) para reparar las lesiones de ssDNA a través de una función no recombinogénica, y en consecuencia son necesarias para la mutagénesis inducida por daño en el ADN. Específicamente, se requieren Rad52, Rad51 y …
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Regulation of Set1-Mediated Methylation of Dam1
… of histone H2BK123 by the E2-E3 ligases Rad6 and Bre1, as well as the Paf1 transcriptional elongation complex. This regulatory pathway exemplifies cross-talk <em>in trans</em> between posttranslational modifications on distinct histone molecules. Set1 has an additional substrate in the …
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Exploring Histone Modifying Complexes with a Proteomic Approach
… einen SET-Bereich und die Dritte ist der Rad6 Komplex aus S. pombe (Sp_Rad6C). Der Set1 Komplex (Set1C) beinhaltet 8 Bausteine, methylisiert Lysin 4 in Histon H3 und ist die erste, entdeckte Histone H3 Lysin 4 Methyltransferase. Es beinhaltet ein Ash2 Homolog (Bre2), einen bekannten …
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From the End to the Middle: Regulation of Telomere Length and Kinetochore Assembly by the RNR Inhibitor SML1
… of Sml1 triggers its ubiquitylation by the Rad6-Ubr2-Mub1 ubiquitin ligase complex and subsequent degradation by the 26S proteasome. Furthermore, I was able to identify novel genes involved in the degradation of Sml1. Of the genes identified, many are involved in the spindle assembly …
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HISTONE-DEPENDENT AND HISTONE-INDEPENDENT PATHWAYS FOR RAD9 CHROMATIN RECRUITMENT AND CHECKPOINT ACTIVATION
… histone H2B-K123 ubiquitylation, carried out by Rad6-Bre1, and histone H3 methylation on lysine 79 (H3-K79), performed by Dot1, contribute to Rad9 recruitment to chromatin. Infact, it has been demonstrated that Rad9 physically interacts with methylated H3-K79 thanks to its Tudor domain. …
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PARKIN, BLM AND EXO1: INVOLVEMENT IN POST-NER ACTIVITY IN NON-REPLICATING CELLS
… of Translesion Synthesis (TLS) polymerases via Rad6-Rad18 mediated monoubiquitination of the Proliferating Cell Nuclear Antigen (PCNA). If this process is impeded, long ssDNA generation and exposure trigger the activation of the DNA damage checkpoint signaling cascade and can potentially lead to …