Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Rad4."”.
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Light-induced modulation of DNA recognition by the Rad4/XPC damage sensor protein.
… the xeroderma pigmentosum C complex (XPC-Rad23B; Rad4-23 in yeast). Rad4/XPC specifically recognizes various bulky helixdestabilizing/distorting lesions in the genomic DNA to initiate the global genome nucleotide excision repair (GG-NER) pathway in eukaryotes. This dissertation reports that …
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Characterisation of non-essential genes required for survival under conditions of DNA stress
… fits the multifunctional description, is TopBP1. Rad4 is the Schizsaccharomyces pombe (S. pombe) TopBP1 homologue that is essential for the initiation of DNA replication, DNA repair as well as the activation of DNA damage checkpoint signalling. We have modelled conditions of replication stress in …
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Deformability and Dynamics in Linear and Looped/Supercoiled DNA with Implications for Damage Sensing
… binding. We studied two repair proteins: 1) Rad4 (yeast ortholog of human XPC), which recognizes DNA lesions from UV-light and other environmental genotoxins and initiates nucleotide excision repair; 2) MutS, which recognizes single mismatches or unpaired nucleotides introduced during …
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Caracterização molecular da mutação pso8-1/rad6 de Saccharomyces cerevisiae, sensível à fotoadição de psoralenos, à radiação UVC e a mutágenos químicos
… assim foi chamado pso8-1. O duplo mutante pso8-1 rad4-4 foi altamente sensível à UVC, indicando assim uma interação sinergística dos dois mutantes alelos. A clonagem molecular pela complementação do fenótipo de sensibilidade à radiação UVC do mutante pso8-1 e estudos genéticos revelaram que pso8-1 …