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Showing 1 to 17 of 17 for “"Racemase"”.
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Mechanistic Investigations of Mandelate Racemase: The Electrophilic Catalysts
MR is a member of the enolase superfamily (Babbitt et al., 1996), which is a family of proteins which are both structurally and mechanistically related. All the family members have highly conserved metal ion ligands. Based on the homology to enolase, which requires two divalent metal ions, MR as …
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Characterization of the Broad-Spectrum Racemase, BsrF, in Vibrio fischeri
… roles are still being elucidated. Broad-spectrum racemases (Bsr), which have been found in several Bacteria and one Archaeon, can catalyze the interconversion of L- and D-isoforms. These Bsrs have a wide range of possible substrates and differ from each other in several ways, such as specific …
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Mechanistic investigations of mandelate-racemase and muconate lactonizing enzyme I
Restriction data tranferred 2014-07-01T11:15:30-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission
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Reinigung und Charakterisierung der alpha-Methylacyl-CoA-Racemase aus menschlicher Leber
… Fettsäuren spielt die alpha-Methylacyl-CoA-Racemase eine wichtige Rolle, indem sie die (R)- und (S)-Isomere von alpha-methylverzweigten Fettsäuren als Coenzym A Thioester racemisiert. Methylverzweigte Fettsäuren entstehen beim Abbau von Isoprenoiden und werden darüber hinaus auch von vielen …
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Toward improved drug discovery against flexible protein targets: an exhaustive study of glutamate racemase conformational dynamics, ligand binding, and catalysis
… work focuses on one particular enzyme, glutamate racemase. Glutamate racemase is an essential and non-redundant enzyme in all species of bacteria, and inhibition of this enzyme results in cell wall degradation, followed by imminent cell death. Inhibitors of glutamate racemase could act as novel …
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Amino acid racemase responsible for the biosynthesis of D-aspartate and D-serine signaling molecules in Aplysia californica central nervous system
… biology and biochemical methods, a d-amino acid racemase 1 (DAR1) has been discovered, cloned and characterized from the Aplysia CNS. The biosynthesis of D-Ser and D-Asp in Aplysia CNS cerebral ganglion F/C neuronal clusters via this enzyme has been characterized; these are the regions where high …
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Mechanistic Enzymology Of Plasmodium Falciparum Sir2, Structural And Biochemical Studies On Nicotinamidases And The Structure And Function Of Enzymes In The Purine Degradative Pathway From Klebsiella Pneumoniae
… (OHCU) decarboxylase and allantoin racemase. The examination of the aminotransferase from K. pneumoniae reveals a novel pathway from ureidoglycine to oxalurate and provides structural evidence for this enzyme's specificity for ureidoglycine. We characterize the first reported …
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Gene der Chinaldin-Degradation in Arthrobacter ilicis Rü61a: Charakterisierung und funktionelle Expression der Chinaldin-4-Oxidase Strukturgene
… der Fumarylacetoacetat-Hydrolasen, eine Mandelat-Racemase, einen TetR-ähnlichen Transkriptionsrepressor und zwei Transmembranproteine.
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Characterization of Ortho-Succinylbenzoate Synthase (Osbs): A Study of Mechanism, Proficiency and Evolutionary Diversity
… that can also function as an ""N-acylamino acid racemase"" (NAAAR). The adventitious racemization reaction catalyzed by this OSBS was characterized in addition to the native reaction. The discovery of a naturally promiscuous enzyme provides support to the theory that enzyme evolution proceeds …
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Discovery of function in the enolase superfamily
… homology model. Many enzymes in the mandelate racemase (MR) subgroup catalyze dehydration of various acid-sugar substrates. Attempts were made to elucidate the biochemical function of previously uncharacterized MR subgroup members from Agrobacterium tumefaciens, Mesorhizobium loti, Polaromonas …
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A STUDY OF BIOSENSORS: NOVEL APPLICATION AND NOVEL ELECTRODE
… prostate cancer biomarker, alpha-methylacyl-CoA racemase (AMACR), had been previously demonstrated to distinguish cancer from healthy and benign prostate cells with high sensitivity and specificity. However, no accurate clinically useful assay has been developed. Therefore, the development of a …
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Measuring D-amino acids in the central nervous system using capillary electrophoresis
… D-Ser can be synthesized endogenously by serine racemase which converts L-Ser to D-Ser. D-Ser can affect the activity of N-methyl-D-aspartate (NMDA) receptor, which is an important receptor involved in learning and memory formation. D-Asp levels correlate with embryonic development stages and …
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Identifizierung und Charakterisierung der Isoflavon-umsetzenden Enzyme aus dem humanen Darmbakterium Slackia isoflavoniconvertens
… das induzierte Protein IfcA als Dihydrodaidzein-Racemase. Diese katalysierte die Umsetzung des (R)- und (S)-Enantiomers von Dihydrodaidzein und Dihydrogenistein zum korrespondierenden Racemat. Neben dem Elektronentransfer-Flavoprotein IfcBC wurden auch die THDR, DZNR und IfcE als FAD-haltige …
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Degradation of xylan by rumen Prevotella SPP
Item reinstated by Sarah Shreeves (sshreeve@illinois.edu) on 2012-05-15T10:00:36Z Item was in collections: University of Illinois Dissertations and Theses (ID: 204) Dissertations - Microbiology (ID: 748) No. of bitstreams: 4 Dodd.Dissertation.Final.pdf: 11501575 bytes, checksum: …
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Analysis, fractionation and exploratory recombinant expression of novel eukaryotic l/D peptide isomerases and free D-amino acid racemases
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-09-01 without embargo terms
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Mining the enolase superfamily for new functions: investigations of D-glucarate dehydratase related proteins (GlucDRP) and L-lyxonate dehydratase proteins (LyxD)
… L-lyxonate dehydratase activity, to a mandelate racemase (MR) subgroup of the enolase superfamily. In vitro and in vivo data were combined here to show that the dehydration of L-lyxonate is the biological role of the enzymes in this protein family. Through in vitro experiment, catalytic …