Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 98 for “"Rac1"”.
-
Nanoscale Organization of The Small Gtpase Rac1
<p>Rac1 is a small, guanine-nucleotide binding protein that cycles between an inactive GDP-bound and active GTP-bound state to regulate actin-mediated motility, migration, and adhesion. Plasma membrane (PM) localization is essential for its biological activity. Rac1 PM targeting is directed by a …
-
Rac1 signaling regulates platelet-dependent inflammation abdominal sepsis
… little is known about the potential role of Rac1 in controlling sepsis-induced intracellular signaling pathways. We hypothesized that Rac1 might be involved in sepsis mediated signaling pathways leading to the activation of inflammatory cells. Paper (I), Rac1 signaling plays an important role …
-
Regulation of Net1A Subcellular Localization By The Small Gtpase Rac1
… the regulation of Net1A isoform localization by Rac1. Specifically, co-expression of constitutively active Rac1 with Net1A stimulates the relocalization of Net1A from the nucleus to the plasma membrane in breast cancer cells, and results in Net1A activation. Importantly, Net1A localization is …
-
The Role of Rac1 in Synaptic Plasticity, Learning and Memory
… transmission in the central nervous system. Rac1, a protein of the Rho subfamily of GTP binding proteins (GTPases), is largely known for its involvement in cytoskeleton remodeling, and has been implicated in neuronal development, participating in the morphological changes required for …
-
RhoA and Rac1 prenylation: Effects on serine/threonine signaling for actin polymerization
RhoA and Rac1 are small guanosine triphosphates (GTPases) that regulate cytoskeletal rearrangements, cell polarity and axon guidance and signaling pathways. Alteration of the subcellular localization or activation of Rho GTPases is implicated in several neurological conditions. Rho GTPases are …
-
Prenylation-independent activation of RhoA and Rac1: Effects on localization and neurite outgrowth
… to injury or insult and growth cone collapse. Rac1, another Rho GTPase, is implicated in regulating cell proliferation, cell cycle entry, and extension of neuronal processes. Both RhoA and Rac1 require prenylation for membrane targeting, which is believed to be required for activation of these …
-
AKR1B10 PROMOTES BREAST CANCER METASTASIS THROUGH INTEGRIN α5/δ-CATENIN-RAC1 SIGNALING PATHWAY
… CANCER METASTASIS THROUGH INTEGRIN α5/δ-CATENIN-RAC1 SIGNALING PATHWAY MAJOR PROFESSOR: Dr. Deliang Cao Aldo-keto reductase 1B10 (AKR1B10) is not expressed in normal breasts, but upregulated in primary and metastatic breast cancers, being a negative prognostic marker. This study characterized the …
-
RAC1-Mediated Actin Cytoskeleton Remodeling and Monolayer Barrier Properties of Stretched Alveolar Epithelial Cells
… remodeling initiated through activation of the Rac1/Rho signaling pathways and resulted in increased monolayer permeability. We have demonstrated that AEC monolayers stretched biaxially undergo rapid magnitude and frequency-dependent actin cytoskeletal remodeling to form perjunctional actin …
-
Mechanisms and Functional Consequences of Cardiac Remodeling: Role of Myocardial Rac1 and Vascular Profilin1 Genes
… data has confirmed the role of myocardial human Rac1 in the development of cardiac remodeling and heart failure in both animal and human patients. However, nothing is known about the effects of nonmammalian Rac protein on the mammalian heart. In an exciting discovery, we showed in chapter 2 of …
-
Rac1 and IRE1 are Required to Prevent Early Loss of Intestinal Homeostasis in Drosophila melanogaster
<p>No abstract available</p>
-
Hyperactive Rac1 Drives MAPK-Independent Proliferation in Melanoma by Assembly of a Mechanosensitive Dendritic Actin Network
… describe how a hyperactivating mutation of the Rac1 GTPase (Rac1P29S) harnesses Rac1's function as a regulator of actin polymer assembly to sustain cell cycle progression in growth limiting conditions. This proliferative advantage supports metastatic colonization of melanoma cells and confers …
-
Αvβ8 Integrin Interacts With Rhogdi1 to Regulate Rac1 and Cdc42 Activation and Drive Glioblastoma Cell Invasion
… due to hyperactivation of the Rho GTPases Rac1 and Cdc42. β8 integrin associates with Rho GDP Dissociation Inhibitor 1 (RhoGDI1), an intracellular signaling effector that sequesters Rho GTPases in their inactive GDP-bound states. Silencing RhoGDI1 expression or uncoupling αvβ8 …
-
Novel Rac1/Stat3 and Stat5 Pathway in Differentiation and Neoplastic Transformation of Breast Epithelial Cells: Potential Prognostic Markers
… Stat3 activation is modulated by a cadherin/Rac1 pathway, and this may be necessary for differentiation. Stat5 on the other hand may play a role in differentiation independent of cell density. Therefore, Stat3 and Stat5 may turn out to be independent prognostic markers for breast cancer. We …
-
A Synthetic Lethal shRNA Screen and Genetic Proof of Concept Identifies RAC1 as a Novel Target to Disrupt Plexiform Neurofibroma Formation
… mice were generated with biallelic deletion of Rac1 (Nf1f/fRac1f/f Postn-Cre+; DKO ). Mice were aged for 9 months and peripheral nerves were harvested and fixed in formalin. Peripheral nerve size was measured and tumors were identified through blinded analysis of hematoxylin and eosin and …
-
Regulation of p190RhoGEF by Activated Rho and Rac GTPases: Amplification and Crosstalk
… from p190RhoGEF bound to either RhoA•GTP or Rac1•GTP. The interfaces between activated Rac1 or RhoA with the PH domain utilize the same hydrophobic surface on the PH domain. Similar to RhoA, activated Rac1 interacts with the PH domain via its effector-binding surface albeit burying less …
-
The role of Ras-related C3 botulinum toxin substrate 1 (RAC1)-dependent pathway in the regulation of uterine function during early pregnancy
… unknown. Our recent studies revealed that RAC1 (Ras-related C3 botulinum toxin substrate 1), a pleiotropic signaling factor belonging to the Rho family of GTPases, is induced in the uterine stroma during decidualization and angiogenesis, suggesting a role for RAC1 in these critical …
-
IQGAP1 is a novel effector of gonadotropin-releasing hormone receptor signaling
… molecular scaffold IQGAP1 and the small GTPase Rac1. Subsequent investigation revealed that the association between Rac1 and IQGAP1 increased with GnRH receptor stimulation and that GnRH increased Rac1 activity. Demonstrating functional relevance, inhibiting Rac1 reduced GnRH-dependent ERK …
-
Molekulare Analyse der Yersinien-Wirtszell Interaktion
… 31 positiv interagierende Klone, die als Rac1 (17 Klone, davon 4 unabhängige), Snk i.p. (11 Klone, davon 6 unabhängige) und Mus musculus spindlin (3 Klone) identifiziert werden konnten. Rac1 gehört zur Familie der Rho-GTPasen zu denen u.a. auch die Proteine RhoA und Cdc42 gehören. Diese …
Page 1 of 5