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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 162 for “"Rac"”.
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The Rac-GEF P-Rex1 Regulates Agonist-Induced GPCR Trafficking
… factors (GEFs) activate the small GTPase Rac following stimulation of a variety of cell surface receptors, including G protein-coupled receptors (GPCRs). By activating Rac, P-Rex proteins control gene expression, cell survival and motility, among other responses, and therefore play …
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New roles of Rac-GEFs in Neutrophils and in Glucose Homeostasis
Rac-GEFs (guanine-nucleotide exchange factors) are proteins that activate Rac GTPases, thereby enabling Rac-dependent cytoskeletal dynamics and cellular processes such as adhesion and migration. I used mice with genetically modified Rac-GEFs to identify new functional roles of these proteins in two …
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Regulation of p190RhoGEF by Activated Rho and Rac GTPases: Amplification and Crosstalk
… from p190RhoGEF bound to either RhoA•GTP or Rac1•GTP. The interfaces between activated Rac1 or RhoA with the PH domain utilize the same hydrophobic surface on the PH domain. Similar to RhoA, activated Rac1 interacts with the PH domain via its effector-binding surface albeit burying less …
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The Role of Rac and Filamin A in Osteoclast Function and Osteoclast Heterogeneity
… in osteoclasts and many other cell types. A Rac GTPase validation experiment was used to prove that osteoclast function is best characterized through three-dimensional (3-D) volumetric analysis of resorption pits (Rpits). The success of this method prompted us to measure Rpits in osteoclasts …
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The Cloning and Characterization of Two ROP/RAC G-Proteins from Gossypium Hirsutum
Rop/Rac proteins are plant-specific monomeric guanosine triphosphate-binding proteins (G-proteins) with important functions in plant development. Until recently, only three cotton (Gossypium hirsutum) Rop/Rac G-protein genes were sequenced, representing subfamilies III and IV of the plant monomeric …
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Upregulation of PIP3-dependent RAC Exchanger 1 (P-Rex1) Promotes Prostate Cancer Metastasis
Activation of Rac by guanine-nucleotide exchange factors (GEFs) at the leading edge of the cell plays an important role in directional cell migration, a critical step of tumor metastasis cascades. We investigated the role of P-Rex1, a novel specific GEF for Rac, in human prostate cancer metastasis. …
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Function and Regulation of Phosphatidylinositol 3,4,5-Triphosphate-Dependent Rac Exchanger 1 (P-Rex1) in Cancer
… hosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 (P-Rex1) promotes tumorigenesis and metastasis of various cancers, and thus could be a potential therapeutic target. The first objective of my study was to determine the molecular mechanism regulating P-Rex1 gene expression. We …
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Rapid Rac GTP-ASE activation in live cells by mechanical stress is independent of Src
… The temporal and spatial activation of Rac, a small guanosine triphosphatase, was quantified using a fluorescent resonance energy transfer (FRET) method that measures changes in Rac activity in response to mechanical stresses by quantifying intensity ratios of ECFP (enhanced cyan …
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Phagocytosis promotes programmed cell death and is controlled by Rac signaling pathway in C. elegans
… rather than simply remove dead cells. We characterized an engulfment pathway and found that ced-2 encodes an adaptor protein similar to human CrkII that physically interacts with the previously identified CED-5 DOCK180 protein and that ced-10 encodes a Rac-like GTPase. ced-10 acts downstream …
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The function of Drosophila Integrin-Dim7-Elmo-Mbc→Rac signaling pathway in the muscle attachment formation and maintenance
… and Cell Motility (Elmo)-(Myoblast city) Mbc→Rac signaling pathway is evolutionarily conserved from C. elegans to vertebrates and is essential for many developmental processes, including phagocytosis and cell migration. Flies that possess mutations in the elmo locus are lethal and exhibit …
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Synthesis, Chemistry, Biological Evaluation And Structure-Activity Relationships Of Rac- And Chiral 6-Desmethyl-5Β –Hydroxy-D-Secoartemisinin And Analogs
… their antimalarial activity. The synthesis of rac-6-Desmethyl-5β–hydroxy-D-secoartemisinin (a 1,2,4-trioxane) afforded a starting point upon which to conduct heretofore unexplored structure-activity relationships (SAR) about the C5 position. Additionally, as the C4 position is quintessential, …
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Translational Control by the Ribosome-Associated Complex in the Unfolded Protein Response
… (NAC) and the ribosome-associated complex (RAC). Mammalian RAC consists of Hsp70L1, an Hsp70 chaperone homologue, and Mpp11, a DnaJ cofactor. RAC interacts with the nascent chain near the polypeptide exit tunnel and the decoding center on the 60S and 40S ribosomal subunits, respectively. Its …
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Effect of ractopamine hydrochloride (Paylean®) on fresh meat and further processing characteristics of muscles from the shoulders of finishing pigs
Ractopamine hydrochloride (RAC), a β-adrenergic agonist, increases muscle mass and decreases fat deposition in the pig. Though RAC has been extensively studied, to date no experiments have quantified its effect on the pork shoulder. Therefore, the objectives of this study were to characterize the …
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Knowledge -the Fifth Element of Hip Hop Music: Mexican and Puerto Rican Youth Engagement of Hip Hop as Critically Rac(ed) Education Discourse
… hop music as critical pedagogy. Using Critical Race and Latino Critical Race theories, the author conducted a multi-methodological qualitative study with twenty Mexican and Puerto Rican youth in Chicago analyzing student's narratives about the influence of race, ethnicity, and culture in their …
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Seismic characterization of recycled aggregate concrete
… but the use of Recycled Aggregate Concrete (RAC) is yet limited to non-structural applications such as road sub-base. Widespread application of RAC in areas such as seismic design requires an improved knowledge of RAC behavior under multiaxial state of stresses. The main objective of this …
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The Effects of Ractopamine Hydrochloride (Paylean) on Efficiency, Carcass Composition, Carcass Quality and Fat Quality in High Lean Growth Pigs
… were conducted to evaluate the effects of ractopamine hydrochloride (PayleanRTM) (RAC) on efficiency, carcass composition, carcass quality and fat quality in high lean growth pigs. The first study evaluated the effect of RAC on growth performance and carcass characteristics of late …
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Effects of feeding ractopamine hydrochloride in combination with zinc or chromium on growth performance, carcass characteristics, and meat quality of finishing steers
… decade. One product available on the market is ractopamine hydrochloride (RAC), a beta-agonist that acts as a nutrient repartitioning agent to shift nutrient deposition from fat to lean tissue. There are other additives which may work in combination with RAC to enhance lean tissue deposition and …
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Processing and properties of recycled aggregate concrete
… materials such as recycled aggregate concrete (RAC) rises, effort, it is important to understand the properties of RAC that relates to its use in construction. To respond to this need, various tests were performed to investigate the properties of RAC. Properties of RAC are highly affected by …
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The effect of two levels of dietary ractopamine hydrochloride (Paylean®) supplementation on growth performance, feed efficiency and quantitative carcass traits in finisher gilts
Ractopamine hydrochloride (RAC) has been used in the pig production industry for over 30 years. RAC is a beta-adrenergic agonist which is supplemented in the feed during the last 28 days prior to harvesting in finisher pigs to modify the pig's metabolism such that nutrients are redirected to favour …
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