Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"Rabbit model"”.
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FRACTURE HEALING IN A RABBIT MODEL: A STUDY OF OSTEOCALCIN LOCALISATION
… fracture healing in tissue sections of adult rabbit tibiae. A peroxidase anti-peroxidase technique and an indirect peroxidase technique were assessed on newly developing bone in human fracture callus. Three antibodies which cross-reacted with human osteocalcin in serum were evaluated for use …
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The Effects of Tracheal Occlusion on Wnt Signaling in a Rabbit Model of Congenital Diaphragmatic Hernia
… purpose of this study was to a) confirm the CDH rabbit model produced PH which was reversed by TO and b) determine the effects of CDH +/- TO on EMT pathways. Methods: CDH was created at 23 days, TO at 28 days and lung collection at 31 days gestation in fetal rabbits. Lung body weight ratio …
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Development and Validation of Large-Sized Engineered Cartilage Constructs in Full –Thickness Chondral Defects in a Rabbit Model
… 3 cm2) directly from a small number of immature rabbit chondrocytes (approximately 20,000), without the use of a scaffold. After characterizing the hyaline-like engineered constructs, the in vivo repair capacity was assessed in a chondral defect model in the patellar groove of rabbits. In vitro …
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Comparison study of Taurolidin, Talc, Tetracycline and Bleomycin Pleurodesis in the Rabbit Model : Analysis of the Taurolidin's effectiveness
… thorough a 10 Fr. silastic trocar catheter to 40 Rabbits. 2 rabbits as control had been only inserted using a 10 Fr. silastic trocar catheter at 30 days after pleurodesis pleural surfaces were graded by gross observation and histologic examination. These scores have been compared. RESULTS: Overall …
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Bone fracture toughness of estrogen deficient rabbits
… histomorphometric analysis in an ovarectomized rabbit model.;No significant differences were found in fracture toughness, porosity, or femoral neck ultimate strength for any treatment group, which may have be from a lack sufficient time for the difference caused by estrogen deficiency and drug …
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Targeted drug delivery within the eye
… to suppress corneal neovascularization in a rabbit model. The data show that highly targeted delivery of the anti-vascular endothelial growth factor protein therapeutic gave a better biological response of suppressing neovascularization with 11,900 times less dosage compared to topical …
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The electrophysiology of the atrioventricular node in normal and failing rabbit hearts
… delay in atrioventricular (AV) conduction in a rabbit model of left ventricular dysfunction (LVD) due to apical myocardial infarction. In this model, AV conduction time increased with increasing pacing rates, suggesting the most likely site of delay is the AV node. The mechanisms by which this …
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Representative ways to analyze and survey changes in long-term electrocardiographic recordings
… quantified and stored. A new experimental model was developed such that the electrocardiogram can be monitored continuously over thirteen weeks. Cardiotoxicity was progressively induced with doxorubicin in a rabbit model, and electrocardiographic progressions from normal state to diseased …
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Emergency delivery of Vasopressin from an implantable MEMS rapid drug delivery device
… the in vivo rapid delivery of vasopressin in a rabbit model. In vitro characterization of device performance found the device capable of reliably and reproducibly delivering 85% of its loaded drug solution. A comparison of intraperitoneal and subcutaneous injections of vasopressin in rabbits was …
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3D Bioprinting Pediatric Trachea
… Lastly, this work investigates an in vivo rabbit model for evaluating tracheal transplants and poses further questions concerning the regenerative capabilities of tracheal cartilage.
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Application of Cell-Derived Extracellular Matrix (ECM) Scaffold on Tissue Engineering Cartilage
… in vitro and in vivo as nude mouse and rabbit model. Chapter I: A porous cell-derived ECM scaffold was prepared with a freeze-drying protocol using porcine chondrocytes. The ECM scaffold had highly uniform porous microstructure by scanning electron microscope (SEM). It showed an average …
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Atrial Arrhythmogenic Substrates: The Role of Structure and Molecular Remodeling
… mechanisms of AF in two clinically-relevant models - the human and canine hearts. We identify structural and molecular substrates responsible for the generation and maintenance of AFl/AF. We then explore the application of a novel low-voltage defibrillation therapy to a rabbit model of atrial …
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Non-invasive shock wave stimulated periosteum for bone tissue engineering
… to the proliferating cambium layer. In a rabbit model, ESW-thickened cambium layer cells were overlaid in situ on a porous calcium phosphate scaffold. At two weeks post-surgery, there was a significant increase in all outcome variables for the ESW-treated group when compared with controls: …
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New Paradigm of Defibrillation: Towards Painless Therapy
… optical mapping techniques and several animal models of ventricular and atrial arrhythmias, we develop and validate several novel low-voltage defibrillation therapies for atrial and ventricular arrhythmias. Several important previous studies on mechanisms of arrhythmia maintenance and …
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Development and assessment of calcium phosphate bone substitutes for orthopaedic applications
… on scaffold dissolution, following which a rabbit model was adopted to assess in vivo efficacy over a 20 week period. Scaffolds were produced which demonstrated desirable architectural properties including 392.2pm average diameter pores and 64.24% porosity. In vitro dissolution was shown to …
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Preformulation Characterization And Formulation Development of Δ9-Tetrahydrocannabinol Prodrugs For Potential Treatment Of Glacuoma
… was undertaken. A high throughput in vitro model to screen the various formulations for transcorneal permeability was also developed. Promising formulations were instilled in vivo in anesthetized rabbit model and tissue concentrations were determined. Earlier formulations reported in the …
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Smoking and High-Fat Diet: Risk Factors Regulating Emphysema Formation
… from an atherogenic diet. Data obtained with a rabbit model of emphysema further demonstrate that matrix metalloproteinase-1 (MMP-1) likely plays a key role in the pathological degradation of the lung extracellular matrix. Together, the studies presented in this thesis indicate that, in addition …
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