Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Rab8"”.
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Rab8 Directs Tubulation and Furrow Ingression During Epithelial Formation in Drosophila Melanogaster
… have remained unclear. This research shows that Rab8, a small GTPase associated with late exocytic trafficking events, demonstrates striking dynamic behaviors <em>in vivo</em>; transitioning from punctate structures to a stable association with the cortex during furrow formation. Active, …
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An investigation of the functional role of GRAB in the context of Rab3, Rab8 and Rab11
… a Guanine nucleotide Exchange Factor (GEF) for Rab8a. Rabin8 participates in a conserved Rab activation cascade which is critical in the formation of primary cilia. Data presented in this thesis has shown that GRAB interacts with Rab3a, Rab8a, Rab11a and Rab11b in a nucleotide dependent manner. …
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LEUCINE-RICH REPEAT KINASE 2 (LRRK2) AT THE CROSSROAD OF INSULIN SIGNALLING AND PARKINSON S DISEASE
… we here demonstrate that LRRK2 phosphorylates RAB8, a small GTP-binding protein involved in the regulation of vesicular trafficking, in a glucose-dependent manner and favors its recruitment to the primary cilium, an antenna-like structure acting as signalling platform to control hormone …
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Molecular mechanisms of exosome secretion
… its guanine nucleotide exchange activity toward Rab8 for the exocytic trafficking of MVEs and exosome secretion. Together, my work suggests that exocytic trafficking of MVEs and exosome secretion is mediated by phospholipids, Rab GTPases, and the exocyst complex, which is regulated by signaling …