Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Rab5"”.
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Rab5 Activation by the Vps9 Domain
… the endocytic pathway, the small GTPases of the Rab5 family serve an essential function in integrating intracellular protein traffic and these cell signaling events. Rab5 proteins exert their influence on protein trafficking only when bound to GTP. A large family of proteins containing a …
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Rab5 Activation by the Vps9 Domain
… the endocytic pathway, the small GTPases of the Rab5 family serve an essential function in integrating intracellular protein traffic and these cell signaling events. Rab5 proteins exert their influence on protein trafficking only when bound to GTP. A large family of proteins containing a …
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Characterisation of Novel Rab5 Effector Proteins in the Endocytic Pathway
… and phagocytosis. Studies on the small GTPase Rab5 have provided important insights into the molecular mechanism of endocytosis and transport in the early stages of the endocytic pathways. Rab5 is a key regulator of clathrin-mediated endocytosis, but in addition, localises to several distinct …
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Rab-domain dynamics in endocytic membrane trafficking
… (TIRF) microscopy, Rab11-, but neither Rab4- nor Rab5-positive vesicles were observed to fuse with the plasma membrane. Rab4-positive membranes, however, could be induced to fuse in presence of Brefeldin A. Thus, these experiments complete the view of the recycling pathway by the following steps: …
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Characterization of Alsin and Its Role in IGF-1-Mediated Neuronal Survival
… is controlled. This is particularly true of Rab5, the Rab protein required for vesicle fusion at the endosome. Endocytosis of plasma membrane proteins requires Rab5(GTP, and humans possess at least seven proteins (Vps9 family) that are expected to activate Rab5. An intriguing aspect of the …
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Deciphering The Role of Huntingtin In Endosomal Functions
… endocytosis into early endosomes regulated by Rab5, the endocytosed cargo can either be recycled back to the plasma membrane (via Rab4/Rab11) or degraded through the endosomal-lysosomal pathway (via Rab7). Disturbances in normal Rab functions could lead to abnormal cargo recycling or …
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Activation of lipid kinase VPS34 by Rab GTPases
… as specific regulators for each complex. While Rab5 is a strong activator for endocytic complex II, Rab1 specifically activates the autophagic complex I. To gain insight into the activation mechanism, I obtained a 9.8 Å resolution structure of complex II bound to Rab5 on membranes, using …
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Characterization of the entry mechanisms utilized by the alphavirus venezuelan equine encephalitis virus to infect mosquito cells
… isolated and characterized in the mosquito cell. Rab5, Rab7 and dynamin are shown to be involved and necessary for VEEV entry and infection in mosquito cells. A novel entry assay is used to confirm that VEEV requires a low pH to enter mosquito cells. This work represents the first characterization …
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Effect of Gender on the Association of Single-Nucleotide Polymorphisms with Bipolar Disorder
… of the ion exchanger SLC24A3 and upstream of the Rab5-interacting protein RIN2 gene on chromosome 20 (rs6046396) yielded very high significance in men (p=3.91 X 10-9).</p>
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Investigation of early endosomal sorting and budding
… benötigt der Prozess die endosomalen Proteine Rab5, Phosphatidylinositol-3-Phosphat und überraschenderweise auch den Dockingfaktor EEA1. Des Weiteren wird die Funktion des N-Ethylmaleimide-sensitiven Faktors (NSF), eines bekannten Fusions-Kofaktors, benötigt, während endosomale Fusion selbst …
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Proteomic analysis of the sorting machineries involved in vesicular traffic between the biosynthetic and endosomal compartments
… and most of the already described effectors of Rab5 microdomains (EEA1, Rabaptin-5, Rabex-5, Vps45) involved in early endosomal dynamics were selectively recruited together with Rab5 and Rab7. Thus, the proteomic analysis of AP-1A and AP-3 coated structures suggest that both AP coats use similar …
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Rab35 Centered Membrane Trafficking Pathway Directs Apical Constriction During Drosophila Gastrulation
… endosomes through a dynamic interaction with Rab5 endosomes. Finally, we find plasma membrane lipid cues in the form of PtdIns(3,4,5)P3 are a critical determinant for Sbf/Rab35 ratcheting engagement. These results suggest that periodic ratcheting events shift excess membrane from cell apices …
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"Molecular Analysis of Virulence Factors Unique to Leptopilina heterotoma-a Parasitic Wasp of Drosophila spp."
… colocalization of VLP was also observed with the Rab5-GFP as well.</p>
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The Interplay of Signal Transduction and Membrane Traffic of the Macrophage Colony Stimulating Factor Receptor (MCSFR) Controls Macrophage Growth
… of the receptor. Following these two steps, the Rab5 positive early endosomes containing MCSFR fuse with nascent macropinosomes and the MCSFR is subsequently transported into the lumen of the macropinsomes and degraded. Pharmacological disruption of macropinocytosis impairs receptor degradation. …
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Regulation of Zebrafish Gastrulation Movements by slb/wnt11
… on cell adhesion appear to be dependent on Rab5-mediated endocytosis, suggesting endocytic turnover of cell-cell contacts as one possible mechanism through which slb/wnt11 mediates its effects on gastrulation movements. - Die Druckexemplare enthalten jeweils eine CD-ROM als Anlagenteil: …
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Mode of Entry and Survival of Salmonella Enterica Serovar Typhimurium in Trophoblast Cells
… indicated that bacteria were arrested in early Rab5 expressing phagosomal vesicles within trophoblast cells, whereas phagosomal maturation progressed steadily in macrophages (with expression of lysosomal-associated membrane protein-1 (LAMP-1) and cathepsin D). Moreover, human primary cTBCs …
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Understanding adipokine secretion and adipocyte-macrophage cellular interactions, in search for the molecular basis of insulin sensitivity and resistance
… expressing non- functional form of Rab11 and Rab5 proteins. However, secretion of leptin, but not adiponectin was inhibited in cells expressing mutants of Protein Kinase D1. These results suggest that leptin and adiponectin secretion involve distinct intracellular compartments and pathways. …
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Investigating the role of PINK1-dependent Rab signalling in Parkinson's disease
… Rab8A total and p-Ser111 co-localised to Rab5 and additional known interactor proteins, however future work is required confirm these interactions occur endogenously and potentially distinguish differential localisation between phosphorylated and unphosphorylated Rab.<br/><br/>I finally …
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Analysis of the maturation of Rhodococcus equi-containing vacuoles in macrophages
… acquired transiently the early endosomal markers Rab5, Ptlns3P, and EEA-1, suggesting initially undisturbed phagosome maturation. Although the RCV acquired some late endosomal markers, such as Rab7, LAMP-1, and Lamp-2, they did not acquired vATPase, did not interact with pre-labeled lysosomes, and …
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Anbindung und Aufnahme von Hitzeschockprotein-Antigenkomplexen durch Antigenpräsentierende Zellen
… Komplexes lokalisiert beladenes Hsp70 in Rab5 positiven retikulären Strukturen, wo es auch im beobachteten Zeitraum auch verbleibt, wohingegen unbeladenes Hsp70 nach 20 min in lysosomalen Kompartimenten zu finden ist. Letztlich konnte mit Hilfe des CD8+ T-Zell Hybridom System B3Z gezeigt …
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