Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Rab35"”.
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Rab35 Centered Membrane Trafficking Pathway Directs Apical Constriction During Drosophila Gastrulation
… to tubular, apical surfaces and associates with Rab35, where it promotes Rab GTP exchange. Interestingly, when Sbf/Rab35 function is compromised, the apical plasma membrane becomes deeply convoluted, and nonuniform cell behaviors begin to emerge. Consistent with this, Sbf/Rab35 appears to …
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Mechanisms of Multivesicular Body Biogenesis and Exosome Release
… In einem weiteren biochemischen Screen wurde Rab35 als Kandidatenprotein identifiziert, dessen die GTP-hydrolyse von TBC1D10A-C spezifisch stimuliert wurde. Eine Hemmung der Funktion von Rab35 blockierte die Exsomenfreizetzung, induzierte die Akkumulation von PLP in den Endosomen und erhöhte …
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Quantitative Aspects of Interface Remodeling During Germband Extension
… extension. The results of this study showed that Rab35 compartments are enriched at contractile interfaces of intercalating cells. When Rab35 function is disrupted, apical area oscillations still occur and contractile steps are observed. However, contractions are followed by reversals and …
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Quantification of Dynamic Epithelial Sheet Architecture in Botryllus Schlosseri Using 2-D & 3-D Image Analysis
… study, the role of membrane trafficking protein Rab35 on interface shortening during germband extension in <em>Drosophila melanogaster</em> was studied. Germband extension (GBE) is a developmental process that drives nonuniform tissue elongation through oriented cell intercalation. During GBE, …
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Helicobacter pylori VacA as a mitochondrial targeted pathogenic effector
… for VacA activity, including 14-3-3-G, VPS4B, Rab35, and Stx18, with Rab53 being important for VacA localization to mitochondria. Furthermore, all constituents of TIM23 and TOM complex were identified, suggesting a potential mechanism of VacA import into mitochondria. In order to evaluate the …
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Role of Bacterial Effectors SopD and SopB in Pathogenicity of Salmonella enterica serovar Typhimurium.
… their targeting. Two of these Rabs, Rab23 and Rab35 were previously shown to promote phagosome-lysosome fusion. Therefore their removal from the SCV may promote SCV trafficking away from the degradative endocytic pathway of host cells. This represents a new mechanism by which an invasion …
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Investigating the role of PINK1-dependent Rab signalling in Parkinson's disease
… four Rabs including Rab10, Rab38, Rab33b and Rab35 were also indirectly phosphorylated across various sites. Large-scale kinase assay screens were employed to identify the direct upstream Rab kinase. Although the Ser111 kinase remained elusive, further novel Thr72 Rab kinases were identified. …