Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Rab10"”.
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Parkinson's Disease-Associated Protein VPS13C Regulates Phospho-Rab10-Mediated Lysosomal Function in Human iPSC-Derived Dopaminergic Neurons
… biochemical approaches identified small GTPase Rab10 as a phospho-dependent novel interactor of VPS13C on lysosomes. Mechanistic studies further elucidated a function for VPS13C together with phosphorylated Rab10 in a lysosomal stress response pathway. Thus, this work establishes a role of …
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Notch Regulates Vascular Collagen IV Basement Membrane Through Modulation of Lysyl Hydroxylase 3 Trafficking
… development. We have identified the GTPase Rab10 as a major regulator of Col IV vesicular trafficking during vascular development using both <em>in vitro</em> imaging and biochemistry as well as in vivo models. Knockdown of Rab10 reduced <em>de novo</em> Col IV secretion <em>in vitro</em> …
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The effects of the Parkinson’s disease-associated proteins LRRK2 and TMEM175 on the lysosomal profile of cultured mammalian cells under lysosomal stress conditions
… mutation were more abundant in phosphorylated Rab10 compared to WT cells. Currently, LRRK2 is considered the major kinase confirmed to phosphorylate Rab10 at T73. However, this work reports increased levels of pRab10 also in LRRK2 KO cells, suggesting that the phosphorylation of Rab10 at the …
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Exploring Parkinson’s disease associated LRRK2 and PINK1/Parkin signal transduction pathways within immune cells
… through use of the highly specific MJFF-pRab10 antibody, which detects Rab10 phosphorylated by LRRK2 at Thr73. I also directly isolated neutrophils from the sputum of CF patients with chronic P. aeruginosa infection, and similarly analysed them for LRRK2 activity, using the MJFF-pRab10 …
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Characterization of Parkinson's Disease-associated LRRK2 Kinase
… a subset of Rab GTPases including Rab8A and Rab10. Moreover, it was shown that LRRK2 PD-associated mutations including G2019S, Y1669C and R1441C/G exhibit an enhanced phosphorylation of Rab10 and Rab8A in cells. Based on this data it was suggested that overactivation of LRRK2, which leads to …
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Investigating the role of PINK1-dependent Rab signalling in Parkinson's disease
… residue whilst a further four Rabs including Rab10, Rab38, Rab33b and Rab35 were also indirectly phosphorylated across various sites. Large-scale kinase assay screens were employed to identify the direct upstream Rab kinase. Although the Ser111 kinase remained elusive, further novel Thr72 Rab …
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Insulin Regulated Trafficking of Glucose Transporter 4: A Kinetic Perspective
… of Rabs 8a, 8b, 10, and 14, and found that Rab10 does regulate release from sequestration, while Rab14 regulates movement of proteins out of early endosomes. This identified a novel AS160-dependent step in Glut4 trafficking. Finally, we characterized the role of Sortilin, and demonstrated …