Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Rab1"”.
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Morphological Remodeling of the Endoplasmic Reticulum During Mitosis and Its Influence on the Integrity of the Spindle Apparatus
… dynamic function at these stages, we identified Rab1. Disrupting <em>Rab1</em> function in the early embryo led to an enhanced buildup of ER at the spindle poles and, interestingly, produced highly penetrant defects in the division cycles. Clustering of ER around the mitotic space is negatively …
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Analysis of Hepatocyte Secretion Pathways: A Case Study on Hepatic Apolipoproteins, Serum Albumin, and Hepatitis C Virus
… involvement. I also investigated the function of Rab1b in hepatic secretion. I show that inactivation of Rab1 function, by expression of a set of dominant negative mutants, or by expression of a bacterial effector which affects Rab1 function, led to impairment of albumin, ApoE, ApoB100 and HCV …
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Interphase chromosome movement during the midblastula transition in Drosophila melanogaster
… I suggest that chromatin is organized beyond the Rab1 orientation such that the position of the gene on the chromosome allows loci to move independently within the active interphase nucleus. I propose a model for chromatin organization within the Drosophila interphase nucleus. Within the Rab1 …
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Activation of lipid kinase VPS34 by Rab GTPases
… is a strong activator for endocytic complex II, Rab1 specifically activates the autophagic complex I. To gain insight into the activation mechanism, I obtained a 9.8 Å resolution structure of complex II bound to Rab5 on membranes, using electron cryo-tomography and subtomogram averaging. Complex …
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Regulatory domains of the Arf GEF Sec7 scaffold autoinhibited and active conformations
… is autoinhibited, and interactions with Rab1, Rab11, Arl1, Arf1 and the membrane recruit Sec7 and stimulate activity. These interactions have been mapped biochemically to the regulatory domains of Sec7, but the precise mechanism of autoregulation has not been established. To identify the …
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Characterisation of a novel Rab18 mouse model for Warburg Micro syndrome
… of the RAB protein network; RAB3GAP1, RAB3GAP2, RAB18 and TBC1D20, causing clinically indistinguishable phenotypes. RAB3GAP1 and RAB3GAP2 form a heterodimeric complex specifically regulating the RAB3 family of proteins in calcium mediated exocytosis of hormones and neurotransmitters. Rab3gap1 …
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A New Approach To Identifying Effectors and Regulators of Small GTPases
… Rab5A (OSBPL9, TBCK), Rab9A (HPS3, NDE1), and Rab11A/B (ALS2). Furthermore, numerous novel interactors were identified for Rab1A and Rab1B, two mammalian paralogues of the yeast protein Ypt1 that are known to be key regulators in ER to Golgi trafficking and suggested to play a role in the …
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Cell Biology of the ICA69 protein family in Neurosecretory cells
… did not show any interaction with Rab2 or Rab1, involved in the anterograde transport between ER and Golgi. Thus, its physiological role remains to be investigated.