Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Rab GTPases"”.
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Activation of lipid kinase VPS34 by Rab GTPases
… by membrane properties and by members of the Rab family of small G proteins, which are important for orchestrating intracellular vesicle sorting and transport. However, their detailed activation mechanisms have been poorly understood. Firstly, we found that high curvature, negative charge, …
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Intracellular Lipid Surveillance Through Interplay Between a Nuclear Receptor and Rab GTPases
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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RabAnalyser: a computational framework to explore the cell-to-cell variability of Rab GTPases organization
L'abstract è presente nell'allegato / the abstract is in the attachment
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Cryo-EM structural exploration of human VPS34 complexes and their activation by RAB GTPases and NRBF2
… VPS34 complexes can be specifically activated by RAB GTPases RAB1A (for complex I) and RAB5A (for complex II), but the mechanistic details of how this specificity is achieved have remained elusive due to a lack of high-resolution structural data for human VPS34 complexes. In this work, I used …
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Anaplasma phagocytophilum remodels its host cell-derived vacuole into a protective niche by redecorating the vacuolar membrane with select Rab GTPases and bacterial proteins
… and Salmonella; selectively recruit host Rab GTPases to their vacuolar membranes to establish replicative permissive niches within their host cells. Rab GTPases coordinate many aspects of endocytic and exocytic cargo delivery. We determined that the A. phagocytophilum-occupied vacuole …
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Identification and characterization of components of rab-6-mediated trafficking in caenorhabditus elegans
… synaptic signaling mechanisms can be controlled. Rab GTPases 6.1 and 6.2 have been profiled for their role in trafficking of GLR-1 in neurons. RAB-6.2 plays a role in the retrograde trafficking of the AMPA-type glutamate receptor GLR-1 (Zhang et al., 2012). Activated Rab GTPases regulate membrane …
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Characterization of Alsin and Its Role in IGF-1-Mediated Neuronal Survival
… movement, and fusion. One class of proteins, the Rab GTPases, is required for docking and fusion of transport vesicles with their target membrane. These proteins are regulated by their state of nucleotide binding, with GTP-bound Rabs thought to provide specificity to transport steps via their …
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Engineering Optogenetic Control of Endocytic Recycling: Controlling Rab11 Function in Drosophila melanogaster using Engineered Light-Responsive Nanobodies
… one main family of transport regulators is the Rab GTPases. Rab GTPases utilize GTP to move materials throughout the cell by binding to the membrane of vesicles or endosomes, and trafficking distinct, membrane-associated components throughout the cell. One member of this large family of proteins …
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An investigation of the functional role of GRAB in the context of Rab3, Rab8 and Rab11
Rab GTPases are the largest family of the Ras superfamily and are key regulators of membrane trafficking within the cell. There are over 60 members of the Rab family which localise to specific membrane compartments and interact with effector proteins to regulate membrane trafficking processes, such …
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Rab-domain dynamics in endocytic membrane trafficking
… molecular understanding of the endocytic system. Rab-GTPases have emerged as architectural key element thereof: Individual family members localize selectively to endosomal compartments, where they recruit a multitude of cytoplasmic effector proteins and coordinate them into membrane sub-domains. …
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Molecular mechanisms of exosome secretion
… activates Akt, which directly phosphorylates Rabin8 and promotes its guanine nucleotide exchange activity toward Rab8 for the exocytic trafficking of MVEs and exosome secretion. Together, my work suggests that exocytic trafficking of MVEs and exosome secretion is mediated by phospholipids, Rab …
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The molecular mechanism of Dual leucine zipper kinase protein localization in neuronal stress signaling.
… local synthesis, diffusion, and degradation. Rab GTPases are crucial in regulating the interaction between cargoes and localization machinery. Moreover, this chapter demonstrates that disruptions in these mechanisms impair proper protein localization, leading to various neurodegenerative …
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Role of Bacterial Effectors SopD and SopB in Pathogenicity of Salmonella enterica serovar Typhimurium.
… alterations driven by SopB result in removal of Rab GTPases from the SCV that depend on electrostatic interactions for their targeting. Two of these Rabs, Rab23 and Rab35 were previously shown to promote phagosome-lysosome fusion. Therefore their removal from the SCV may promote SCV trafficking …
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The interrelationship between the endosomal sorting regulators RAB21, Retromer and WASH complex
… interact with other membrane organisers such as Rab GTPases like RAB21. RAB21 is previously shown to influence the cargo sorting process of specific cargoes based on recent work from Pr Jean laboratory. The primary purpose of this project is to understand the interrelationship between the …
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Characterizing Roles of Host Cell Trafficking Factors in HIV Assembly and Release
… endogenous tagging of host cell Rab GTPases, to investigate the post-endocytic trafficking of Env in physiologically relevant CD4+ T cell lines. We found that endocytosed Env traffics to Rab14+ late endosomes and lysosomes, where it is retained mostly without being degraded, and …
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Identification and Characterization of Effectors/Binding Molecules for the Small GTPase Rab15
… called the pericentriolar recycling\r\nendosome. Rab GTPases regulate specific membrane trafficking steps including vesicle\r\nbudding, vesicle transport and fusion with downstream target compartments. Rab\r\nfunction is mediated by the cyclical binding and hydrolysis of GTP, which in …
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Deciphering The Role of Huntingtin In Endosomal Functions
… largely remains elusive.</p> <p>Rab proteins, part of the Ras superfamily of small GTPases, govern cargo trafficking through endosomal pathways. Upon endocytosis into early endosomes regulated by Rab5, the endocytosed cargo can either be recycled back to the plasma membrane (via …
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Investigating the role of PINK1-dependent Rab signalling in Parkinson's disease
… neurodegenerative disorder. As PD remains incurable, only symptomatic treatment is available for patients. To identify targets for therapeutic intervention and also recognise early stage disease biomarkers, current research revolves heavily around the known genetic causes of PD. These gene …
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Characterization of Parkinson's Disease-associated LRRK2 Kinase
… discovered that LRRK2 phosphorylates a subset of Rab GTPases including Rab8A and Rab10. Moreover, it was shown that LRRK2 PD-associated mutations including G2019S, Y1669C and R1441C/G exhibit an enhanced phosphorylation of Rab10 and Rab8A in cells. Based on this data it was suggested that …
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The Structural and Biochemical Characterization of Salmonella Host Specificity Determinant Gifsy-2 Gene E
… of the Salmonella-containing vacuole by cleaving Rab GTPases, Rab29, Rab32, and Rab38, thereby preventing the delivery of antimicrobial products to the vacuole. In order to gain an understanding of GtgE's proteolytic mechanism, we determined the structure of GtgE to 1.65Å using single-wavelength …
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