Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"RXR"”.
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Regulation of oligodendrocyte lineage cell function by the RXR$\gamma$ nuclear receptor
… potential is compromised. The nuclear receptor RXR$\gamma$ is an important positive regulator of OPC differentiation and an accelerator of endogenous remyelination in aged rats. RXR$\gamma$ functions as a ligand-induced transcription factor and is able to regulate gene transcription. It does so …
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Strategies of overexpressing retinoid X receptor and pregnane x receptor for functional studies
… transcription factor retinoid X receptor (RXR) forms a DNA binding heterodimer with pregnane X rseceptor (PXR) in response to foreign xenobiotics. In addition to RXR and PXR there are other proteins involved in the RXR/PXR signaling pathway. Many proteins involved in this pathway are still …
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Retinoid X Receptor as a Mediator of Post Stroke Recovery by Reversing Age-Associated Phenotypes of Microglia/Macrophages
… poor recovery after stroke. Retinoid-X-receptor (RXR) is a pleiotropic transcription factor. Our studies suggest that RXRa enhances MF phagocytic functions, reduces inflammatory responses, and improves post-stroke recovery. To establish phenotypes of aging MF, MG were MACS-sorted from the brains …
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Elucidation of the Retinoid Signalling Pathway Involved in Axon Guidance in Lymnaea stagnalis and Xenopus laevis
… acid receptor (RAR) and retinoid X receptor (RXR), to mediate gene transcription. Moreover, RA has been shown to act as a guidance molecule for growth cones of regenerating motorneurons of the pond snail, Lymnaea stagnalis. Our lab has recently shown that RA can induce this morphological …
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Retinoid X Receptor activation reverses age-related deficiencies in myelin debris phagocytosis and CNS remyelination
… of genes involved in the retinoid X receptor (RXR) and peroxisome proliferator-activated receptor (PPAR) pathways are decreased with ageing in both myelin-phagocytosing human monocytes and mouse macrophages. Disruption of RXR and PPAR using synthetic antagonists in young macrophages mimics …
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Anti-Inflammatory Mechanism By Oxysterols In Cultured Rat Brain Astrocytes
… conclude that these effects are mediated by LXR/RXR heterodimers. Next, these inhibitory effects of oxysterols also appeared and were potentiated by RXR agonist in IFN-stimulated astrocytes. Furthermore, iNOS expression was inhibited by oxysterols and synthetic LXR ligands in LPS-stimulated …
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Magreceptorok ligandkötési affinitásának vizsgálata FRET szenzorral
… alfa receptor (RAR) és retinoid x receptor (RXR) magreceptorok ligandkötési affinitását vizsgáltam a ligandkötő doménjük (LBD) konformációváltozása révén. Olyan DNS konstruktokat (plazmidokat) kellett létrehoznom, amelyekben a receptorok ligandkötő doménje fluoreszcens festékek szekvenciái …
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“Differential regulation of PTHrP gene expression by 1,25(OH)2D3 in prostate cancer cell lines”
… but not in PC-3, cells. The retinoid X receptor (RXR) is a frequent heterodimeric partner of the VDR. We show that RXRα forms part of the nuclear protein complex that interacts with nVDREhPTHrP with the VDR in LNCaP, C4-2, and PC-3 cells. The RXR ligand 9-cis-retinoic acid (9-cis-RA) …
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Phenobarbital Induced Transcriptional Activation of CYP2B Genes by Chromatin Modification at the PBRU Region
… binds to the NR sites as a heterodimer with RXR and activates CYP2B gene expression. To understand mechanisms by which the CYP2B genes is repressed in the untreated animal and by which CAR activates transcription, first, the repression of CAR transactivation by short heterodimer receptor …
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Identification and characterization of retinoic acid-induced morphological and electrophysiological changes in an invertebrate nervous system
… acid receptors (RARs) and retinoid X receptors (RXRs). Recently, mounting evidence from many animal models has implicated a number of RA-mediated effects operating independently of gene transcription, and thus highlights nove~ nongenornic actions of RA. For example, recent work utilizing cultured …
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Comparative Plasma Proteomics in Muscle Atrophy Induced by Cancer Cachexia and Hindlimb Unloading
… and liver X receptor/retinoid X receptor (LXR/RXR) and farnesoid X receptor/retinoid X receptor (FXR/RXR) activation. Conclusion: Plasma proteomic profiles are altered in cancer cachexia and disuse-induced atrophy. Modulated protein profiles suggest the possibility of multi-tissue involvement …
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Transcriptomics of environmental enrichment and cocaine reveals roles for retinoic acid signaling and ΔFosB in addiction
… different binding proteins, Crabp2 mediated RAR-RXR activation and Fabp5 mediated PPAR-RXR activation. In order to manipulate the two intracellular pathways, the expression of two RA binding proteins was decreased in the NAc shell. Knocking down Crabp2 resulted in anxiogenic and depression-like …
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An investigation of novel therapeutic strategies for the treatment of multiple sclerosis and autoimmunity
… in vitro, owing to literature reporting that RXR ligands augment RAR agonists’ effect on murine Th17/iTreg cells. We show that bexarotene promotes the differentiation of human Foxp3+ iTregs from naive CD4+ T cells independent of RAR engagement, whilst concomitantly inhibiting the …
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Promoting and measuring remyelination and neuroprotection in clinical trials of people with multiple sclerosis
… In animals, agonism of the retinoid X receptor (RXR)-γ enhances remyelination in this way. Metformin also promotes remyelination, this time by overcoming an age-associated block to the responsiveness of OPCs to pro-differentiation factors. In this PhD I show that bexarotene, a non-selective …
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The Effect of HACE1 on RAR Protein Stability
… acid receptors (RAR) and retinoid X receptors (RXR), modulates their transcriptional activity. The AF-1 and AF-2 domains mediate the transcriptional activity. The ligand dependent activation of the AF-2 domain by RA is well understood to involve chromosome decompaction in the presence of ligand …
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The Effect of Retinoic Acid on Rai1 and Identification of Retinoic Acid Receptor Binding Site in Human Rai1
… sites selected in silico are able to bind RAR/RXR heterodimers, to prove the selected sites are real RARE sites and were not identified by chance.
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The Regulation of Cholesterol Absorption: Nuclear Hormone Receptors and Niemann-Pick C1 Like 1
… alpha (PPAR alpha ) and retinoid X receptor (RXR). Thus, cholesterol absorption can be regulated by nuclear receptor modulation of NPC1L1 expression.
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Das Ecdysonsystem zur induzierbaren Genexpression in Herzen von transgenen Mäusen
… beim BombyxEcR der Heterodimerisierungspartner RXR nicht kotransfiziert werden. In Bezug auf erreichbaren Induktionsfaktor und Kinetik der Genexpression zeigten sich für die beiden Systeme vergleichbare Ergebnisse. Weiterhin wurden durch Pronukleusinjektion transgene Mäuse erzeugt, die den …
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Investigating the Role of the PGF2 Alpha/Calcineurin-Signaling Pathway in the Regulation of Adipogenesis
… heterodimerize with its nuclear partner protein, RXR. Additional experiments reveal that the PGF2α/calcineurin-signaling pathway induces expression of Nurr1 via the action of the CREB transcription factor, and more specifically, its association with members of the calcineurin-sensitive, …
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Characterization of HPPD-inhibitor resistance in waterhemp (Amaranthus tuberculatus)
… HPPD inhibitor-resistant waterhemp (MCR) and RxR progeny (derived from greenhouse crosses of HPPD-resistant waterhemp) with an HPPD inhibitor-sensitive biotype. Subsequent resistant-to-sensitive (R/S) ratios revealed a 9-to 13-fold level of resistance. Finally, Chapter 5 includes a summary of …
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