Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"RVFV"”.
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Characterization of Innate Immune Mechanisms Against RVFV and a Potential Target for Antivirals
Rift Valley fever virus (RVFV) is a mosquito-borne zoonotic pathogen, which affects both humans and livestock. RVFV belongs to the Bunyaviridae family, genus Phlebovirus and consists of a tripartite genome (L-, M- and S- segments). NSs, encoded in the S- segment promotes degradation of PKR and …
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The development of novel diagnostic countermeasures for Rift Valley fever virus
Rift Valley fever virus (RVFV) is a zoonotic arbovirus that is a significant threat to livestock and humans. It is listed as #3 for most dangerous animal threats and is in the top 10 pathogens needing urgent research in preventative and control measures. Although RVFV has never been reported in the …
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Investigating the mechanism of RNA packaging in Rift Valley Fever phlebovirus
Rift Valley fever phlebovirus (RVFV) is a trisegmented, single-stranded, negative-sense RNA genome, consisting of L, M and S segments. The virion carries two envelope glycoproteins, Gn and Gc, along with ribonucleoprotein complexes (RNPs), composed of encapsidated genomes carrying the nucleocapsid …
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Characterisation of the immune modulatory effect of wild type Rift Valley fever virus strains
Rift Valley fever Phlebovirus (RVFV) ist ein Mitglied der Familie Bunyaviridae. Es wird durch Stechmücken übertragen und ist in der Lage zahlreiche Wirtspezies zu infizieren. Beim Menschen kann die Infektion zu Hepatitis, hämorrhagischem Fieber und Enzephalitis mit tödlichem Ausgang führen. Bei …
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INNATE IMMUNITY IN ENCEPHALITIC BUNYAVIRUS INFECTION: OVERCOMING NEURONAL VULNERABILITY
… prominent examples are Rift valley fever virus (RVFV), and La Crosse virus (LACV). These viruses may preferentially infect neurons due to dampened neuronal innate immune responses. Innate immunity, including the antiviral interferon (IFN) and inflammatory NF-κB pathways, coordinates host …
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Development of Rift Valley fever virus candidate vaccines and reagents produced in Nicotiana benthamiana
… negative-stranded RNA Rift Valley fever virus (RVFV). It belongs to the genus Phlebovirus in the family Bunyaviridae. The virus is spread by infected mosquitoes and affects ruminants and humans, causing high numbers of neonatal fatalities in animals and occasional fatalities in humans. It is …
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The Impact of the Non-Structural Small Segment Gene on Host Immune Responses Against Rift Valley Fever Virus
Rift Valley fever virus (RVFV) is responsible for large periodic outbreaks of enzootic hepatitis of ruminants. Inevitably, due to the close proximity and relationship between, the mosquito vector species, livestock, and humans, infection spreads to humans causing a range of mild to severe clinical …
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Manipulation of the Rift Valley Fever Virus M-Segment for Vaccine Development
Rift Valley fever virus (RVFV) is a phlebovirus of the virus family, Bunyaviridae. Since the early 1900s, RVFV has continually caused economically devastating outbreaks in livestock and severe disease in humans. In pregnant ewes, RVFV infection can cause abortions in up to 100% of animals and high …
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Comparison of the two lumpy skin disease virus vaccines, Neethling and Herbivac, and construction of a recombinant Herbivac-Rift Valley fever virus vaccine
… LSDV expressing Rift Valley fever virus (RVFV) genes. An LSDV vaccine is critical for sustainable control of lumpy skin disease (LSD). There are four commercially available live attenuated vaccines for LSDV, nLSDV, Herbivac, Lumpyvax and the Kenyan strain sheeppox virus (KS-1). In this …
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Epidemological investigations of rift valley fever in livestock in three ecological zones of Malawi.
… to detect presence of Rift Valley fever virus (RVFV) antibodies in serum. Questionnaire survey and the sero-positivity data, were analyzed for quantitative results using descriptive statistics. Bivariate analysis for association was conducted using Pearson chi-square and univariate linear …
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Epidemiological investigations of rift valley fever in livestock in three ecological zones of Malawi.
… to detect presence of Rift Valley fever virus (RVFV) antibodies in serum. Questionnaire survey and the sero-positivity data, were analyzed for quantitative results using descriptive statistics. Bivariate analysis for association was conducted using Pearson chi-square and univariate linear …
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Discovering LC3-interacting region (LIR) motifs in hemorrhagic fever viruses: Implications for host autophagy and viral replication.
… therapeutic targets. Rift Valley fever virus (RVFV) is a HFV that causes significant disease in humans and livestock and was an initial model HFV for the present study. The RVFV nonstructural small (NSs) protein is the main virulence factor of RVFV and we discovered four novel LC3-interacting …
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Host response to Rift Valley fever virus infection
Rift Valley fever virus (RVFV) has the ability to cause severe disease (in the form of encephalitis or hemorrhagic fever) in humans and animals. RVFV is endemic to parts of Africa and the Arabian Peninsula, but there is significant concern regarding its potential introduction into non-endemic …
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Understanding Host-Pathogen Interactions of Rift Valley Fever Virus That Contribute to Viral Replication
Rift Valley fever virus (RVFV) is a negative-sense RNA virus that is classified as an overlap select agent by the USDA and the HHS. It was first discovered in the Rift Valley of Kenya in the early 1930s. RVFV is an arbovirus that is transmitted by mosquitoes and infects ruminants and humans. RVFV …
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Characterization of genetic reassortment and recombination potentials between Arumowot Virus and MP-12 vaccine strain
Rift Valley fever virus (RVFV) is a zoonotic arbovirus that causes significant morbidity and mortality in both humans and animals. In humans, the disease manifests itself as febrile illness, hemorrhagic fever, encephalitis, or retinitis. In animals, RVFV causes high rates of abortions and fetal …
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Reverse genetics system and fucntion of NSM protein of Rift Valley fever virus (family Bunyaviridae, genus phlebovirus)
Rift Valley fever virus (RVFV) (genus Phlebovirus, family Bunyaviridae) has a tripartite negative-strand genome, causes a mosquito-borne disease that is endemic in sub-Saharan African countries and results in large epidemics among humans and livestock. Furthermore, it has potential as a …
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The study of ancient viral class II envelope fusion proteins within the viral retroelements of Nematoda and the nuclear plasmids of Dictyostelium
… transcript that share features with a modern RVFV-like M-segment and likely represents another ancient class II fusion protein. Why this plasmid carries a complete set of fusion machinery and whether it forms infectious virus-like particles is yet to be determined. Regardless, the presence of …