Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"RUNX3"”.
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Regulation of RUNX3 in gastric and breast cancer
RUNX3 is a transcription factor that is ubiquitously expressed in different tissues and has been shown to have diverse functions in many developmental procedures. Recently it has also been acknowledged that RUNX3 is involved as a tumor suppressor in many distinct cancers in different tissues. In …
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Twist1 and Etv5 are part of a transcription factor network defining T helper cell identity
… mechanisms including physical interaction with Runx3 and impairing STAT4 activation. Following induction by STAT3-activating cytokines including IL-6, Twist1 represses Th17 and Tfh differentiation by directly binding to, and suppressing expression of, the Il6ra locus, subsequently reducing STAT3 …
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The role of lactate in CD4+ T cell differentiation and function
… Th1 cells greatly upregulated expression of RUNX3, Eomes, GZMB and Perf-1, whereas L-lactate samples showed a more discreet effect. Lactate addition impacted histone acetylation state and metabolic activities like OXPHOS and glycolysis. However, none of these parameters were responsible for …
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Identifying regulators of natural killer cell development through CRISPR screening of common lymphoid progenitors
… of NK cell development such as *Nfil3*, *Runx3* and *Eomes*. Additional putative regulators, such as *Tcf3* (encoding E2A), *Rere*, *Bach1* and *Zfp652* were identified and validated using arrayed CRISPR screens. Due to the known role of *Tcf3*/E2A in the decision between the innate and …
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Exploring the adaptive immune response to Oncogene-Induced-Senescence
… upregulated 45 gene transcripts. This included Runx3 and Ccl5 involved in tissue residency and HCC-associated hepatic immunosurveillance, respectively. I attempted to utilise the Antigen-Receptor Signalling Reporter (AgRSR) mouse, a novel lymphocyte-activation tracing mouse model that permits …