Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"RU486"”.
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Hormonal modulation of sex steroid hormone receptors and oncogenes in human breast cancer cells
… effects on ER. R5020 and the antiprogestin RU486 (10 nM) both reduced PR mRNA levels by 50% but did not change HER-2/neu. In T47D cells, which contain low ER and high PR levels, E$\sb2$ induced ER mRNA 2.5-fold in 2d. In contrast, R5020 reduced both ER mRNA and PR mRNA levels to 20% of …
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Cervical Remodeling/ripening At Term And Preterm Delivery: The Same Mechanism Initiated By Different Mediators And Different Effector Cells
… one by administration of progesterone antagonist RU486. Increased cervical C3 deposition and macrophage infiltration and increased serum C3adesArg and C5adesArg levels were observed in both models when compared to gestational age matched controls. A significant increase in collagen degradation, …
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A mouse model to study inducible oncogene cooperation <i>in vivo</i>
… receptor (hPR891) that is sensitive to RU486 and not to endogenous progesterone.<br></br><br></br> With thesef usedo ncogeneist is possible to activate only Ras( with tamoxifen) or only Myc (with RU486) or both (providing both tamoxifen and RU486).<br></br><br></br> Moreover the activity …
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The glutamate hypothesis of depression: the effect of stress and glucocorticoids on glutamate synapse and the action of antidepressants
… receptors (MR). The preincubation with RU486, selective GR antagonist, and spironolactone, selective MR antagonist, prevented the CORT-induced increase of RRP. Contrary to acute stress, CORT by itself did not promote vesicle fusion, since CORT application in vitro did not increase …
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Increase of glucocorticoids is not required for the acquisition, but hinders the extinction, of lithium-induced conditioned taste aversion
… sucrose–lithium pairing. Dexamethasone, but not RU486, pretreatment diminished the formation of lithium-induced CTA memory. Dexamethasone prior to each drinking test suppressed sucrose consumption and prolonged the extinction of lithium-induced CTA. Sucrose consumption was significantly …
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Characterization of Rapid Nongenomic Cortisol Signalling in Rainbow Trout Liver
… were identified on the plasma membrane, RU486 had no effect on CREB signalling or ROS generation in vitro, suggesting that these endpoints are GR-independent. Also, cortisol did not rapidly affect the transcript abundance of glucocorticoid-responsive genes associated with the …
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Development of inducible transgenic mouse models for melanoma
… bigenic EICre/N-Ras mice. Treatment with Ru486 initially apparently failed to exhibit an abnormal phenotype, despite confirmation of N-Raslys61 expression following hair plucking to initiate the hair cycle and anagen melanocytes proliferation, therefore PTENflx/flx mutation was introduced. …
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Differential effects of progestogens on HIV-1 replication and host gene expression in primary PBMCs and cervical tissue explants
… molecular clones (IMCs). The GR antagonist RU486 or GR siRNA knockdown was used to determine the role of the GR in modulating ligand-specific effects. PBMCs and primary cervical explants were chosen as useful models to assess the direct effects of these progestogens in both the systemic and …
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Differential Endometrial Responses of Primates vs Rodents: Screening for Antiproliferative Effects of Antiprogestins
<p>The antiprogestin, mifepristone, has previously been shown to noncompetitively inhibit estrogen-induced endometrial proliferation in nonhuman primates (van Uem et al., 1989; Wolf et al., 1989b; Neulen et al., 1990; Neulen et al., 1996). For both economical and ethical reasons, we are encouraged …
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Synergism between immune activators and progestogens: differential effects on gene expression and HIV-1 replication and the role of the glucocorticoid receptor
… The role of the GR was investigated using RU486 or GR siRNA knockdown. Mucosal barrier integrity and permeability was assessed by confocal microscopy and transepithelial electrical resistance measurements. For infection assays, TZM-bl cells were exposed to HIV-1Bal-Rellina infectious …