Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"RTK signalling"”.
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Studying lung development in vitro: expanding the genetic toolbox and analysis of SOX2 and SOX9 function
… SOX9 connects WNT and receptor tyrosine kinase (RTK) signalling pathways, both of which drive lung epithelium development. SOX9 expression is regulated by canonical WNT signalling and SOX9 modulates the expression of ETV4 and ETV5, which are RTK signalling effectors, thereby influencing RTK …
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Investigating the mechanisms and outcomes of Sprouty-2 S-acylation
… are regulators of Receptor Tyrosine Kinase (RTK) signalling and play a major role in maintaining cellular homeostasis. Indeed, their deregulation is linked to tumorigenesis, developmental defects and neurological diseases.;The defining feature of SPRY proteins is a large cysteine-rich domain …
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Investigations of collective cell movement during gastrulation in the chick embryo
… response was not mediated by tyrosine kinase (RTK) signalling. Inhibition of major classes of RTKs expressed in chicken gastrulation failed to abolish chemotaxis, however the serum response was sensitive to pertussis toxin (PTX), a potent inhibitor of Gai/o signalling. Uniform FBS concentration …
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The Roles of EGFR and FGFR2 in Cell Shape Maintenance of Human Lung Tip Progenitor Epithelial Cells
… I used the organoid system to identify signalling pathways that maintain the shape of human lung tip progenitor cells. I have found that EGF, FGF7 and FGF10 have distinct functions in the regulation of lung tip progenitor cell shape. FGF7 promotes columnar cell shape in primary tip …
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Investigating the mechanisms by which PINK1 protects against Parkinson's disease
… pro-survival, neuroprotective and anti-stress signalling functions. Autosomal recessive mutations in PINK1, resulting in a loss of PINK1 function, cause early onset Parkinson’s disease (PD). This thesis aimed to investigate the mechanisms by which PINK1 protects against PD, with a focus on …