Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"RTK signaling"”.
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Mechanistic Characterization of RTK Signaling Networks Using Phosphoproteomic Approaches
… stems from aberrant gene expression and protein signaling. In order to improve development of novel therapeutics, underlying mechanisms employed by malignant cells to maintain their function need to be deeply understood. The field of phosphoproteomics has advanced over the past few decades to …
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Characterization of split ends, a new component of the Drosophila epidermal growth factor receptor signaling pathway
… regulator of the receptor tyrosine kinase (RTK) signaling pathway. Molecular characterization of spen has revealed that spen encodes a protein with 5476 amino acids. It contains three tandem repeats of an RNA Recognition Motif (RRM) at its N-terminus, suggesting that Spen might function as …
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Dissecting mechanisms and consequences of oncogenic RTK fusion signaling
Receptor tyrosine kinase (RTK) fusions are a large class of oncoproteins found in ~5% of cancers. Despite development of targeted therapies for cancers driven by fusion oncogenes, drug resistance remains a significant challenge, in part because we still lack a clear understanding of the broader …
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Estradiol Regulation of Leucine-Rich Repeat Immunoglobulinlike Domains Protein 1 (Lrig 1) and Roles of Estrogen Receptor in Translational Regulation in Breast Cancer Cells
… negative regulator of Receptor Tyrosine Kinase (RTK) signaling. Up-regulation of LRIG1 mRNA and protein is mediated by the estrogen receptor-alpha (ERalpha) and we identified the regions of the LRIG1 gene to which ER binds. LRIG1 regulation by estradiol helps to explain how tumors typically …
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Characterisation of genetic and epigenetic aberrations in paediatric high grade glioma
… 1/17 (6%) case. Genes involved in reelin/PI3K signaling (DAB1), RTK signaling (PTPRE), and arginine biosynthesis (ASS1 and ASL) were frequently deregulated by methylation in these tumours. The anti-growth and anti-migratory properties of DAB1 and PTPRE were demonstrated in vitro. Preliminary …
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Using Xenopus laevis to study the mechanisms governing the early germline development and the formation of vertebrate body plan
… in Xenopus. Receptor tyrosine kinase (RTK) signaling is used repeatedly during Xenopus embryogenesis to establish the body plan. Ligand-independent activation of RTKs allows dissecting the receptor-specific signaling outcomes from the pleiotropic effects of the ligands. In this regard, …
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Estradiol regulation of leucine-rich repeat immunoglobulin-like domains protein 1 (LRIG 1) and roles of estrogen receptor in translational regulation in breast cancer cells
… negative regulator of Receptor Tyrosine Kinase (RTK) signaling. Up-regulation of LRIG1 mRNA and protein is mediated by the estrogen receptor-α (ERα) and we identified the regions of the LRIG1 gene to which ER binds. LRIG1 regulation by estradiol helps to explain how tumors typically utilize …
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Predicting angiogenic receptor trafficking and signaling via computational systems biology
… complex formation implies a possible VEGFR1 signaling role beyond its classically defined decoy status. In this dissertation, I introduce a computational approach that accurately predicts the cell response elicited via VEGFR1 signaling. I show that VEGFR1 promotes cell migration through PLCγ …
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Systematic Identification of Interaction Partners of RET Receptor Isoforms
… a library of SH2 domain-containing adaptor and signaling proteins, to screen for interactions with each RET isoform. Through different steps of analysis of MaMTH screen data, we narrowed down RET potential interactors. We complemented these studies by ranking our SH2 prey library using sequence …