Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 90 for “"RTK"”.
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Axl RTK and microRNAs in urogenital cancers
… focused on the Axl receptor tyrosine kinase (RTK) and microRNAs in clear cell renal cell carcinoma (ccRCC) and in prostate cancer (PCa). Paper I focuses on differentially expressed microRNAs in ccRCC. We used bioinformatics methods to identify candidate microRNAs in a publically available …
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Dissecting mechanisms and consequences of oncogenic RTK fusion signaling
Receptor tyrosine kinase (RTK) fusions are a large class of oncoproteins found in ~5% of cancers. Despite development of targeted therapies for cancers driven by fusion oncogenes, drug resistance remains a significant challenge, in part because we still lack a clear understanding of the broader …
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Mechanistic Characterization of RTK Signaling Networks Using Phosphoproteomic Approaches
… when evaluating function of AXL, another RTK that has been associated with acquired resistance to EGFR-targeting tyrosine kinase inhibitors. We applied phosphoproteomic analysis to explore the regulation of EGFR by phosphatase PTPRJ as a potential indirect mechanism of modulation. Beyond …
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OPSEC v. RTK: Media Restrictions in United Nations Peacekeeping
The United Nations currently adopts media policies for peacekeeping missions on an ad-hoc basis, often relying on US or NATO rules. Some have suggested that a standardized media policy for all peacekeeping missions should be the norm. This project examines that proposition with an eye to the …
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Peer PPP-RTK: toward an affordable real-time high accuracy service
… the performance of a high accuracy GNSS PPP-RTK (Precise Point Positioning- Real Time Kinematic) operational framework based on a dense network of peer users, through the exchange of precise Ionospheric and Tropospheric estimates between peers. The PPP-AR (PPP Ambiguity Resolution) technique, …
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GNSS Integrity Monitoring with Modelling Temporal Correlated Measurement Noise and an Application to RTK
… with an application to real-time kinematic (RTK) positioning. An approach based on colored Kalman filter (CKF) is presented which considers measurement time correlation by a first-order autoregressive model and rebuilds a new measurement model for the CKF. The state variance matrix obtained …
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Systems modeling of quantitative kinetic data identifies receptor tyrosine kinase-specific resistance mechanisms to MAPK pathway inhibition in cancer
… of targeted or bypass receptor tyrosine kinases (RTKs). While the latter is often attributed to gene amplification, genetic characterization of tumor biopsies has failed to explain substantial proportions of resistance. We hypothesize that post-synthesis mechanisms governing RTK levels may …
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Characterization of split ends, a new component of the Drosophila epidermal growth factor receptor signaling pathway
… regulator of the receptor tyrosine kinase (RTK) signaling pathway. Molecular characterization of spen has revealed that spen encodes a protein with 5476 amino acids. It contains three tandem repeats of an RNA Recognition Motif (RRM) at its N-terminus, suggesting that Spen might function as …
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Cells and force transduction
… on the respective receptor tyrosine kinase (RTK) binding partner of cadherin. This involvement of RTKs at cadherin complexes is important in propagating force transduction globally, implying that force transduction at cadherin complexes is not restricted to cell-cell junctions but is also …
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Synthesis of furo[2,3-d]pyrimidines, thieno[2,3- d]pyrimidines, pyrrolo[2,3-d]pyrimidines as classical and nonclassical antifolates, receptor tyrosine kinase (RTK) inhibitors and antimitotic agents
… areas of antifolates, receptor tyrosine kinase (RTK) inhbitors and anti mitotic agents has been discussed. Thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFTase) are important folate dependent enzymes that are targets for cancer …
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Computer Vision Applications in Structural Engineering
… 2. Structural Shape Monitoring Using an RTK enabled UAV with GCP-Free Georeferencing: This study investigates the feasibility of the structural shape monitoring approach consisting of a Real-time Kinematic (RTK) enabled Unmanned Aerial Vehicle (UAV) and georeferencing without Ground …
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Comparison of topographic information from various sources for engineering design
… 8 ppsm. Total station and real time kinematic (RTK) surveys have also been conducted and the total station data are used as the standard by which LiDAR will be evaluated. Anecdotal experiences have suggested that LiDAR data appear accurate, but overall the elevations are uniformly too high or …
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Desenvolvimento de plataforma robótica com sistema de navegação autônoma para aplicação na agricultura de precisão
… por Satélite com Cinemática em Tempo Real (GNSS-RTK), enfrenta desafios de custo e integração eficiente de Unidade de Medição Inercial (IMU) para precisão na navegação. A utilização de componentes de baixo custo possibilita fomentar a automação na agricultura de precisão e aumentar a …
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Factors That Affect the Global Positioning System and Global Navigation Satellite System in an Urban and Forested Environment.
… GPS and GLONASS satellite observations using RTK techniques in an urban and forested environment. To determine this accuracy, 2 data sets of 3-dimensional coordinates were created and compared at 14 stations situated at East Tennessee State University. One data set included coordinates …
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DNA Damage-dependent Regulation and Function of akt-1 in Caenorhabditis elegans
… the Insulin-like receptor tyrosine kinase (RTK) DAF-2, the class I PI3K AGE-1 and the 3-phosphoinositide-dependent protein kinase 1 (PDK1) homologue PDK-1. This pathway ultimately controls the action of Akt homologues on the forkhead transcription factor DAF-16. The C. elegans Akt orthologue …
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Einfluss des Tyrosinkinaseninhibitors PTK 787/ZK 222584 auf Vaskularisation und Wachstum intracerebraler Gliome der Ratte
Einfluss des VEGFRezeptor-2 spezifischen RTK-Inhibitors PTK 787/ ZK 222584 auf Angiogenese und somit Wachstum maligner Gliome in einem Tiermodell. Verwendet wurden hierbei C6-Rattengliomzellen aus denen durch retrovirale Transfektion von VEGF cDNA in sense Richtung ein stark VEGF exprimierender …
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Smartphone precise positioning in urban environments using internal GNSS and IMU sensors
… limitations of both PPP and Real-Time Kinematic (RTK) techniques, a novel PPP/RTK hybridization algorithm with smartphone Inertial Measurement Unit (IMU) integration is proposed. Additionally, this research explores the utilization of the available Galileo HAS corrections for smartphone …
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Estradiol Regulation of Leucine-Rich Repeat Immunoglobulinlike Domains Protein 1 (Lrig 1) and Roles of Estrogen Receptor in Translational Regulation in Breast Cancer Cells
… negative regulator of Receptor Tyrosine Kinase (RTK) signaling. Up-regulation of LRIG1 mRNA and protein is mediated by the estrogen receptor-alpha (ERalpha) and we identified the regions of the LRIG1 gene to which ER binds. LRIG1 regulation by estradiol helps to explain how tumors typically …
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Multivariate studies of receptor tyrosine kinase function in cancer
Receptor tyrosine kinases (RTKs) are critical regulators of cellular homeostasis in multicellular organisms. They influence cell proliferation, migration, differentiation, and transcriptional activation, among other processes, and are therefore also relevant to cancer biology. Upon interaction with …
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