Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"RTB"”.
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Engineering of the RTB Lectin as a Carrier Platform for Proteins and Antigens
… specific lectin ricin B-chain (RTB) is especially attractive in possibly fulfilling a carrier role due to its well-characterized endocytotic trafficking and its efficacy over a wide range of cell types. By producing RTB recombinantly in plants it is possible to create a fully …
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Ricin B Chain-Insulin Fusion Protein Immunomodulation of Type 1 Diabetes
… The human proinsulin (INS) ricin toxin B chain (RTB) fusion protein was expressed in <em>Escherichia coli </em>and purified for use in an animal inoculation experiment to test for the suppression of diabetes symptoms. Non-obese diabetic (NOD) mice were orally inoculated and boosted with purified …
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Development of Random Triblock Copolymer Based Nanoparticulate Formulation for Sustained Release of Macromolecules/Biologics in Treatment of Posterior Segment Ocular Diseases
Random triblock copolymers (RTB) were successfully synthesized by ring opening copolymerization method. RTB copolymers are composed of FDA approved materials such as polyethylene glycol (PEG), glycolide (GA), lactide (LA) and ɛ-caprolactone (CL). RTB copolymers were synthesized and developed for …
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Enterotoxin B Subunit Lectins as Adjuvants for Improvement of Mucosal Vaccine
… (STB) and monomeric ricin toxin B subunit (RTB) molecules were genetically linked to a 90 amino acid peptide from the simian rotavirus (SA11) nonstructural protein NSP4 or to the rotavirus outer capsid protein VP7. Lectin binding assays were used to demonstrate receptor binding activity of …
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Plant-derived Murine IL-12 and Ricin B-Murine IL-12 Fusions
… cytokine, and whether the plant lectin RTB can facilitate mucosal delivery of IL-12 to immune responsive sites. Transgenic tobacco plants expressing murine IL-12 were generated and characterized. To ensure stochiometric expression of the two separately encoded, disulfide-linked subunits …
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A study on the flow characteristics of an industrial radiant tube burner
… air in an industrial radiant tube burner (RTB). The RTB is used typically in industrial heat treating furnaces. The work has been initiated because of the need for improvements in burner lifetime and performance which are related to the fluid mechanics of the com busting flow, and a …
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Bat Activity Across Urban Forest Plantings in Lexington, Kentucky
… efforts, such as Reforest the Bluegrass (RTB) in the Lexington-Fayette metropolitan area of Kentucky, have been implemented to address these negative effects, and to create habitat for forest-dependent wildlife such as bats. My research focused on assessing differences in bat activity …
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Role of Membrane Contact Sites in the Neuropathogenesis of GM1-Gangliosidosis
… aspects of the GM1-gangliosidosis mice, using an RTB-conjugated recombinant β-Gal that has the ability to cross the blood brain barrier. Results. In the first set of results, we used TEM to demonstrate that β-Gal KO neurons have a significantly higher number of ER-PM junctions than WT neurons. …