Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"RT-QuIC"”.
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Lessons from Tau RT–QuIC: Structure, Kinetics, and Drug Discovery
… using the Real–Time Quaking–Induced Conversion (RT–QuIC) assay for the selective amplification of tau filaments from human brain homogenates. By harnessing the self-propagating nature of amyloid aggregates, this approach enables the sensitive amplification of ex vivo seeds through the strategic …
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Evaluating suspected CWD feral pig brain samples using RT-QuIC and protocol for the purification and quality control of recombinant monomeric proteins for RT-QuIC assay
… <p>wasting disease (CWD) history, study, and further interests leads the paper. This is followed</p> <p>by a chapter on analysis of feral pig brainstem by RT-QuIC to determine the presence or</p> <p>absence of aggregated prion protein. The next chapter is dedicated to describing a protocol</p> …
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Intravital diagnostics of neurodegenerative diseases
… Zlatým štandardom preto zostáva priama post-mortem detekcia patologicky zložených proteínov v mozgovom tkanive pomocou western blotu a imunohistochémie. Avšak v posledných rokoch sa pre ultra-senzitívnu ante-mortem diagnostiku zaviedli metódy so spoločným názvom ʺseeding amplification assays …
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Amyloid seeding assays for the selective amplification of tau aggregates from human brain homogenates
… (4R, Progressive supranuclear palsy, PSP; corticobasal degeneration, CBD; others), or a combination of 3R/4R tau aggregates (Alzheimer disease, AD; chronic traumatic encephalopathy, CTE; primary age-related tauopathy, PART). This work details several methods for the selective detection and …