Global ETD Search
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Showing 1 to 5 of 5 for “"RSAM"”.
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Biosynthetic and bioinformatic investigation of RiPPs with radical SAM-installed crosslinks
… crisis. Radical S-adenosylmethionine enzymes (rSAM) are responsible for producing intriguing and complex molecules, some of which are antibiotics. These enzymes have been demonstrated to catalyze C-C, C-S, C-O-C, and C-N crosslink formation among other fascinating modifications. However, there …
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Investigations Into the Function of Elp3 in Toxoplasma Gondii
… and its radical S-adenosyl methionine (rSAM) domain is important for the formation of tRNA modifications, which enhance translation efficiency and fidelity. Given its location, histones would not be an expected substrate, and we further determined that tubulin acetylation in Toxoplasma …
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Characterization of Cyclopropyl Synthases Involved in the Maturation of Ribosomally Synthesized and Posttranslationally Modified Peptides
… Recently, radical-S-adenosylmethionine (rSAM) enzymes have emerged as an important family of RiPP maturases. rSAM enzymes have been shown to install ether, thioether, and carbon-carbon bonds on the precursor peptide. These modifications usually define the backbone structure of the mature …
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Post-translational modifications of methyl-coenzyme m reductase in methanosarcina acetivorans
… be synthesized by a B12-dependent radical SAM (rSAM) enzyme, designated MgmA. In Chapter 2, we show that two different MgmA homologs are able to methylate MCR in vivo when expressed in Methanosarcina acetivorans, an organism that does not normally possess this PTM. M. acetivorans strains …
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Řízení bezpečnosti a kontrolní aktivity použité v firemním prostředí
Cílem této práce bylo popsat řízení bezpečnosti a kontrolní mechanizmy, které jsou používané v korporátním prostředí. Práce se zabývá teoretickým popisem standardů používaných pro aplikační bezpečnost, dále popisuje nástroje určené pro získavání informací o firemním prostředí, které mohou být …