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Showing 1 to 5 of 5 for “"RS domain"”.
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Charakterisierung von Cyclin L2 : ein neuer Vertreter der Cyclin-Familie
… combines the unique combination of cyclin domain and arginine-serine-rich domain (rs-domain). These rs-domains comprise a hallmark for splicing factors. The intention of this thesis was to characterize cyclin L2 and to analyze the interaction between DYRK1A and cyclin L2. Application of a …
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Identifizierung von Cyclin L2 und des Spleißfaktors SF3B1 als Substrate der Proteinkinase DYRK1A
… investigations. Cyclin L2 combines a cyclin domain with an arginine-serine-rich (RS)-domain and was extensively characterised in this work. Alternatively spliced transcripts were identified and their expression in different tissues was analysed. The results demonstrate that the RS-domain of …
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Design, synthesis, and analysis of conjugated activators for modulation of alternative splicing
… Splicing is controlled by SR proteins, factors which bind to exonic splicing enhancers (ESEs) through RNA binding domains and recruit the splicosome via protein-protein interactions mediated by their RS domains, protein domains rich in highly charged arginine-serine dipeptides. Defects in …
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Characterization of U2AF26, a Paralog of the Splicing Factor U2AF35
… (RNP-2) and significant differences within the RS domain, two regions thought to be important for the function of U2AF35. The goal of this study was to characterize the functional differences between the two small subunits. Western blot analysis revealed that U2AF26 protein expression varies …
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Kristallstrukturanalyse des spleißosomalen DEAD-Box Proteins hPrp28
… die zum aktiven Spleißosom und zur ersten Transester-Reaktion führt. Vermutlich katalysiert hPrp28 dabei an der 5 -Spleißstelle der prä-mRNA den Austausch der U1 snRNA gegen die U6 snRNA. In dieser Arbeit wurde die C-terminale Helikasedomäne von hPrp28 kristallisiert und seine …