Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 59 for “"RS Pharmacy and materia medica"”.
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PULMONARY DELIVERY OF PNEUMOCCOCAL VACCINE USING NANOCOMPOSITE MICROPARTICLE CARRIERS VIA DRY POWDER INHALATION
… human pathogens, causing high morbidity and mortality rates globally. Although there are vaccine available such as PPV 23, PCV7, PCV10, and PCV13, they are ineffective in some situations due to the differing epidemiology of various serotypes depending on the site of infection and the …
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QUALITY HEALTHCARE IN NHS HOSPITALS: THE IMPACT OF PRESCRIBING SYSTEMS
… to go paperless by 2018, more hospitals in England are making the transition from paper to electronic prescribing (ePrescribing) systems. The aim of this programme of work was to understand and explore the influence different in-patient prescribing systems can have on key NHS healthcare …
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Experimental spectroscopic and theoretical studies of amino acid derivatives
… circular dichroism spectroscopic and theoretical studies of amino acid derivatives, i.e. N-acetyl-L-Asp, N-acetyl-L-Glu, and di-amino acid peptide/derivatives, i.e. L-Asp-L-Glu, a-N-acetyl-L-Asp-L-Glu, and ß-N-acetyl-L-Asp-L-Glu are reported. The calculated structures for …
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Colloidal microgels as (trans)dermal drug delivery systems
… microgels have been used as novel drug carriers (i.e. a novel controlled drug delivery system) for either dermal or transdermal delivery. The experiments conducted in this project were, firstly, to investigate the uptake and release of model compounds with different physico-chemical properties …
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Topical pharmacokinetics for a rational and effective topical drug development process
… as oral drugs. The process is more uncertain and contains gaps. This leads to a poor discharge of risks before going to the clinical phases. The topical drug development process is reviewed in the introduction of the thesis. In particular, past and current topical drug development practices …
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The kinetics of ion release by glass-ionomer cements
Ten brands of GIC were used in this study: four commercial conventional GICs, one in-house conventional GIC made from G338 glass powder, one commercial glass-ionomer bone cement and four in-house novel aluminium free Fe2O3 based GICs. Cylindrical specimens of GICs were prepared in stainless steel …
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The development of chemically engineered pullulan for drug delivery
… modified carboxymethyl pullulans (HMCMPs), and crosslinked carboxymethyl pullulan). The foregoing modifications were performed in two steps from the parent pullulan. The first step involved carboxylation of pullulan with sodium chloroacetate yielding carboxymethyl pullulan (CMP). The second …
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Developing a New Model of Care for Patients' Medication Supply at Hospital Discharge: A Multi-Perspective Approach
… is a complex process that can result in errors and delays for patients, particularly around the supply of medicines and communication of information. This programme of work (PoW) aimed to develop an innovative model of care for the supply of medication at hospital discharge to provide safe, …
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Development of an electronic aerosol atomisation system for generating three-dimensional (3D) cells in microencapsulations and microtissues characterisation
… is a micro technology widely applied in cell and tissue engineering, tissue transplantation and regenerative medicine. Various techniques had been developed for microencapsulation of cells but these techniques presented threat to the cells due to the harsh or chemical treatment applied. In …
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Studies investigating the preparation of solid core drug delivery systems for oral delivery of y-globulin via supercritical fluid processing technology
… oral delivery. However, several physicochemical and biological barriers pose as a challenge for the use of biomolecules as oral drug therapies. Solid core drug delivery systems (SCDDS) allow for immobilization of these molecules on a solid surface to improve and maintain their stability, followed …
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Subcutaneous and oral delivery of insulin
… project was to prepare, optimize, characterize and compare a subcutaneous/oral delivery system for insulin. The effect of various low molecular weight chitosans (LMWCs) on the stability of insulin, using USP HPLC methods, was investigated. Insulin was found to be stable in a polyelectrolyte …
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Formulation of novel buccal mucosal drug delivery systems for nicotine replacement therapy (NRT)
Hydroxypropylmethylcellulose (HPMC) and sodium alginate (SA) were used in the formulation of composite wafers and films for potential nicotine (NIC) replacement therapy via the buccal mucosa route. Composite blank (BK), drug loaded (DL) HPMC-SA films (optimized with 2% w/v plasticizer) and wafers …
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Studies into solid core drug delivery system using haemoglobin as a model drug and supercritical fluid processing for encapsulation
… oral delivery of proteins using silica as core material, haemoglobin as model drug and supercritical fluid processing as encapsulation technique. Silica particles of different morphology were used as a carrier material for protein immobilisation and fatty acids coating was performed using …
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Formulation and characterisation of novel films for buccal mucosa drug delivery for paediatric patients
… project was to develop, formulate, characterise and optimise novel pre-formed thin polymer film that will deliver therapeutically relevant drugs via the buccal mucosa route of paediatric patients, using OME as model drug. The development focused on obtaining formulations with optimized drug …
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Hot melt extrusion (HME) processing for the development of lipid oral solid dosage forms
… matrices. The use of lipids instead of polymers is a novel approach with distinct advantageous. Sustained release solid lipid matrices of diclofenac sodium (Df-Na)/Compritol® 888 ATO (888 ATO) prepared using different approaches such as ‘cold’, ‘hot’ and pre-mix’ by applying changes in …
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The preparation of solid core drug delivery system (SCDDS) via supercritical processing of fatty acids
… drug delivery system for biologics i.e. proteins and peptides using a solid core drug delivery system (SCDDS). Both, 0.5 μm and 1.0 μm silica particles were used as a model core material and were coated with different ratios of fatty acid. A proportional increase in particle size was observed with …
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Analysis of drug polymorphism by diffuse reflectance visible spectroscopy- a novel approach
… has implications for therapeutic performance, handling and storage. This study investigates the development of a novel approach to surface analysis of drug polymorphs, with the aim of extending the capabilities of this approach to perform real time analysis of polymorphic transformation during …
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Investigation of membrane permeation using ATR-FTIR spectroscopic imaging and multivariate target factor analysis
… Fourier transform (ATR-FTIR) spectroscopy and ATR-FTIR spectroscopic imaging was used for the in vitro monitoring of the mechanisms of drug permeation and the effects of penetration enhancers on silicone membrane and human stratum corneum (SC). Simulated spectroscopic imaging data sets were …
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Computational Methods in Support of Chemical Risk Assessment
… emerge for the safety assessment of chemicals and to assess chemicals for which testing is not routinely required. The application of TTC relies heavily on computational (in silico) methods. In silico tools are computer implemented models that, based on commonalities in the toxicity of …
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