Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"RRE RNA"”.
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The Rev-mediated Dimerization of HIV RRE RNA
… and assembles on the Rev Response Element (RRE), a 351nt region contained within singly and unspliced HIV RNAs. This ribonucleoprotein (RNP) complex allows for the export of these RNA transcripts encoding viral structural proteins and genomic RNA to the cytoplasm. Of particular interest is …
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The Rev-mediated Dimerization of HIV RRE RNA
… and assembles on the Rev Response Element (RRE), a 351nt region contained within singly and unspliced HIV RNAs. This ribonucleoprotein (RNP) complex allows for the export of these RNA transcripts encoding viral structural proteins and genomic RNA to the cytoplasm. Of particular interest is …
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Structure determination of an HIV-1 RRE RNA-Rev peptide complex by NMR spectroscopy
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1996.
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Functionalizing Branched Peptides with Unnatural Amino Acids Toward Targeting HIV-1 RRE RNA and Microbials
… of the protein Rev with Rev Response Element (RRE) RNA is critical to the HIV-1 life cycle as this complex is required for the export of singly-spliced and unspliced mRNAs from the nucleus to the cytoplasm. Disruption of this interaction is considered to be a powerful strategy towards the …
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Branched Peptides Targeting HIV-1 RRE RNA and Structure-Activity Relationship Studies of Spinster Homolog 2 Inhibitors
… of the Rev protein with Rev Response Element (RRE) RNA present in singly- and unspliced mRNA transcripts is necessary for the replication of HIV-1. This interaction transports the mRNA transcripts from the nucleus to the cytoplasm for translation of the necessary structural and enzymatic …
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Die Rolle von eIF-5A und Kernaktin bei Kernexportprozessen
… Nach der Bindung von Rev an eine spezifische RNA Sekundärstruktur, das sogenannte Rev Response Element (RRE) interagieren zelluläre Faktoren mit dem NES von Rev, wodurch der Kernexport vermittelt wird. Neben dem generellen Exportrezeptor CRM1 konnte auch der eukaryotische Initiationsfaktore 5A …
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Targeting HIV-1 RNAs with Medium Sized Branched Peptides Featuring Boron and Acridine-Branched Peptide Library Design, Synthesis, High-Throughput Screening and Validation
RNAs have gained significant attention in recent years because they can fold into well-defined secondary or tertiary structures. These three dimensional architectures provide interfaces for specific RNA-RNA or RNA-protein interactions that are essential for biological processes in a living system. …
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Targeting Alternative Conformational States of the HIV-1 Rev Response Element Stem IIB using Small Molecules
<p>RNAs are growing in their importance as regulators in multiple biological processes. A deep understanding of how RNAs function within cells requires an understanding of their dynamic behavior to enable the targeting of RNA in drug discovery as therapeutics. The HIV-1 Rev response element (RRE) …