Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"RRE"”.
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The Rev-mediated Dimerization of HIV RRE RNA
… and assembles on the Rev Response Element (RRE), a 351nt region contained within singly and unspliced HIV RNAs. This ribonucleoprotein (RNP) complex allows for the export of these RNA transcripts encoding viral structural proteins and genomic RNA to the cytoplasm. Of particular interest is …
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The Rev-mediated Dimerization of HIV RRE RNA
… and assembles on the Rev Response Element (RRE), a 351nt region contained within singly and unspliced HIV RNAs. This ribonucleoprotein (RNP) complex allows for the export of these RNA transcripts encoding viral structural proteins and genomic RNA to the cytoplasm. Of particular interest is …
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Structure determination of an HIV-1 RRE RNA-Rev peptide complex by NMR spectroscopy
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1996.
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Functionalizing Branched Peptides with Unnatural Amino Acids Toward Targeting HIV-1 RRE RNA and Microbials
… of the protein Rev with Rev Response Element (RRE) RNA is critical to the HIV-1 life cycle as this complex is required for the export of singly-spliced and unspliced mRNAs from the nucleus to the cytoplasm. Disruption of this interaction is considered to be a powerful strategy towards the …
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Branched Peptides Targeting HIV-1 RRE RNA and Structure-Activity Relationship Studies of Spinster Homolog 2 Inhibitors
… of the Rev protein with Rev Response Element (RRE) RNA present in singly- and unspliced mRNA transcripts is necessary for the replication of HIV-1. This interaction transports the mRNA transcripts from the nucleus to the cytoplasm for translation of the necessary structural and enzymatic …
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Molecular Studies involving the Rev Protein of Caprine Arthritis Encephalitis Virus and Visna Virus.
… their mRNAs to the cytoplasm by binding to the RRE (Rev Response Element) found on their mRNAs. Previous studies have indicated that Rev may be toxic to transfected cells, overexpression of exogenous RREs or a better binding RRE can inhibit Rev activity and Rev-C (CAEV Rev) can …
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Targeting Alternative Conformational States of the HIV-1 Rev Response Element Stem IIB using Small Molecules
… as therapeutics. The HIV-1 Rev response element (RRE) RNA which is a known drug target mediates the export of incompletely-spliced viral RNA to express viral proteins required for HIV-1 replication and spread. Rev protein first recognizes the purine-rich region on RRE stem IIB (RREIIB), and then …
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Targeting HIV-1 RNAs with Medium Sized Branched Peptides Featuring Boron and Acridine-Branched Peptide Library Design, Synthesis, High-Throughput Screening and Validation
… replication pathway and Rev response element (RRE)/Rev export pathway. To efficiently target TAR and RRE RNA, we designed and synthesized three generations of branched peptide libraries that resulted in medium sized molecules. The first generation of BPs were discovered from screening a …
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Construction of an HIV-1 subtype C ventor system for phenotypic drug resistance studies
… A mammalian derived plasmid pCMVGagPol(lndieC)RRE comprising unique Apal and Hpal restriction sites was previously modified. Viral RNA from 14 drug narve patient samples was reverse transcribed to cDNA using transcriptor reverse transcriptase thereafter amplified using nested PCR. The amplified …
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Knowledge, Perceptions, Beliefs and Behaviors Related to the Prevention of Hypertension Among Black Seventh-day Adventists Living in London
… weight and waist circumference were and current lifestyles practices were evaluated for the presence of HTN risk factors.</p> <p>Of the 312 volunteers, ages 25 to 79, 55% were born in the Caribbean, 10% in Africa and 35% in the UK. Sixty-nine percent were female and 31% male. Descriptive …
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Targeting RNA Structures with Multivalent Branched Peptide Libraries
… element (TAR) and the Rev response element (RRE). In addition to discovering a mid-nanomolar branched peptide ligand for TAR, the first branched boronic acid peptide library designed to target RNA was screened for binding to RRE. Each of these efforts resulted in the identification of …
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Analysis of Protein and RNA Interactions of the HIV-1 rev Protein
… of viral RNA, termed the Rev Response Element (RRE), which is located in the <em>env</em> region of unspliced and singly-spliced HIV-1 mRNA. The Rev nuclear export sequence (NES) then mediates translocation of the viral transcript to the cytoplasm, allowing for translation of viral structural …
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Evaluating the Conservation of RNA Packaging Enhancer Elements Across Lentiviruses
… in FIV 34TF10 had no impact either, although the RRE was disposable in the SIVmac239 system but necessary in FIV34TF10. This study shows that the GRPE is likely specific to HIV-1.
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Radiocarbon reservoir effects in the American bottom flood plain of the Mississippi River and adjacent uplands in southern Illinois
Radiocarbon reservoir effects (RREs) occur when the 14C activity in a system does not maintain equilibrium with atmospheric 14CO2 activity. Within aquatic systems, old (14C-depleted) carbon may dilute the current carbon pool by soil erosion, decomposition of old botanical and fauna remains, and …
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A study of thermal decompositions of an allylic hydroperoxide /|nby Thomas A. McCarrick. -- 260 St. Catharines [Ont.] : Dept. of Chemistry, Brock University,
… which predicts the multi t ude of products which Rre observed e xperimentally as well as giving activation energies and log A factors si~il a r to those found experimentally .
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Die Rolle von eIF-5A und Kernaktin bei Kernexportprozessen
… das sogenannte Rev Response Element (RRE) interagieren zelluläre Faktoren mit dem NES von Rev, wodurch der Kernexport vermittelt wird. Neben dem generellen Exportrezeptor CRM1 konnte auch der eukaryotische Initiationsfaktore 5A (eIF-5A) als ein Bindungspartner von Rev identifiziert …
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Characterizing peptide-modifying enzyme activity in RiPP biosynthesis
… assignments. Using alkylation-assisted HMBC correlations, it was demonstrated that these products also contain 5TO resulting in a revision of these previously reported structures. The role of 5TO-containing peptides in copper detoxification was investigated and this emerging class of …
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The role of circadian rhythms in reproduction: development and fertility in the bmal1 null mouse.
… (E-box sequences) or RORA response elements (RRE) in their promoter regions. It was revealed that many of the genes investigated contained one or more circadian E-box and RRE sequence, providing a mechanism for the disruption of circadian gene expression within the ovary to cause detrimental …
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Click Chemistry on DNA and Targeting RNA structure with Peptide Boronic Acids
… that as the size of diamondoid increased, a corresponding increase in melting temperature of hybridized duplexes was observed. The developed method has the potential to complement existing DNA ligation procedures for applications in biotechnology and diagnostics. Interest in peptides …
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Charakterisierung membranverankerter HIV-Fusionsinhibitoren
… ermöglicht, dass die Mutation die Funktion des RRE nicht beeinträchtigt und die HR1/HR2-Bindung verbessert.
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