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Showing 1 to 5 of 5 for “"RQC"”.
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Insights into the mechanisms of translation surveillance using constitutive RNA binding ASC-1 complex mutants
… such as ribosome-associated quality control (RQC), have evolved to limit the pro- teostatic damage caused by truncated nascent polypeptides associated with stalled ribosomes. During RQC, the stalled ribosome is removed from its substrate mRNA through the splitting of its component subunits by …
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Structure and Function of the ER-Membrane Complex
… cytoplasmic ribosome associated quality control (RQC). I proceed reproduce my observations with parallel experiments for CFTR$\Delta$F. In order to develop our mechanistic understanding of the EMC I set out to solve the structure of the yeast EMC. Structural characterisation via cryo-electron …
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Translational tuning pre-emptively modulates protein folding and secretory pathway defects
… reducing ribosome abundance, or by impairing the RQC pathway. This suggests ribosome collisions as a causative factor for reduced Yor1 biogenesis in the absence of Eap1. I further show that mRNAs encoding polytopic membrane proteins globally show low ribosome abundance, with Yor1 amongst the …
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Molecular recognition of aberrant translation
Protein translation is a fundamental, demanding process which requires several million ribosomes and consumes as much as 75% of cellular energy. Because of its importance, translation is regulated at many levels to maintain its high fidelity, with both substrates and synthesized products monitored …