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Showing 1 to 2 of 2 for “"RPN13"”.

  1. Structural and biophysical analysis of the proteasomal deubiquitinase, UCH37

    Morrow, Marie Elizabeth

    … its C-terminal KEKE motif to the C-terminus of Rpn13, a proteasomal ubiquitin receptor which ensnares polyubiquitinated prey for degradation. UCH37 is known to be catalytically activated upon binding to Rpn13, allowing cleavage of Lys48-linked polyubiquitin chains from their distal end, an …

    purdue-thes Repository record

  2. Polyubiquitin chain editing by UCH37 promotes degradation of a subset of proteasome substrates

    Dillon, Andrew Liam, author, Yao, Tingting, advisor, Cohen, Robert, committee member, Schauer, Grant, committee member, Ross, Eric, committee member, Prenni, Jessica, committee memberColorado State University. Libraries2025

    Branched polyubiquitin can serve as a priority signal for proteasomal degradation by enhancing proteasomal degradation of modified substrates relative to substrates modified with homotypic K48-linked polyubiquitin chains. UCH37, a proteasome-associated deubiquitinating enzyme (DUB), has been shown …

    colostate Repository record