Global ETD Search
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Showing 1 to 5 of 5 for “"RPE cell"”.
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Effect of Anti-fibrotic Drug (Pirfenidone) on TGF-β Signaling Pathway in Ocular Fibrotic Disorders
… role in transforming retinal pigment epithelial (RPE) cells into mesenchymal fibroblastic cells, which are implicated in fibrotic disorders of the retina. Herein, the effect of pirfenidone, a novel anti-fibrotic agent, on TGF-β1-mediated fibrogenesis in the human RPE cell line (ARPE)-19 was …
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Modulation of cell morphology and function using synthetic biodegradable polymers
… into thin films for use as scaffolds for cell transplantation and guided tissue regeneration. We evaluated the ability of PLGA films to provide a suitable template for directing specific cell growth and tissue formation using cells derived from retinal pigment epithelium (RPE) as an in …
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In vitro evaluation of Ultraviolet Radiation (UVR) exposure of the Retinal Pigmented Epithelium (RPE) and its relevance to Age-Related Macular Degeneration (AMD)
… of cultured retinal pigmented epithelium (RPE), the loss of which heralds advanced AMD, to specific wavelengths of UVR across the UV-B and UV-A bands. METHODS: Using a custom built in vitro UVR exposure apparatus coupled with bandpass filters we exposed the immortalised RPE cell line, …
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Iron-induced Complement Dysregulation in the Retinal Pigment Epithelium: Implications for Age-Related Macular Degeneration
… other possible factors. The formation of extracellular deposits, termed drusen, below the retinal pigment epithelial (RPE) cell layer in the outer retina is a pathognomonic hallmark of AMD. The composition of drusen is complex, but identified elements include iron, complement components, and …
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Biochemical Investigations of Macular Degeneration: The Significance of Protein Oxidation including Novel Methods for Its Study
<p>The retinal pigment epithelium (RPE) is a monolayer of cells located directly behind the photoreceptor cells in the retina. These cells are involved in a variety of functions that support the visual process in the eye, namely 1) they form a blood-retina barrier which separates the neural retina …