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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 154 for “"ROS production"”.

  1. Targeting Mitochondrial ROS Production in Kidney Transplantation

    Beach, Timothy ElliottUniversity of Cambridge2020

    … of mitochondrial reactive oxygen species (ROS) production, thought to initiate many of the downstream pathways resulting in IRI, has been described. This mechanism has identified a number of new therapeutic targets within mitochondria, including the respiratory complex succinate …

    cambridge Repository record

  2. Investigating complex I dynamics and ROS production in ischaemia-reperfusion injury

    Burger, NilsUniversity of Cambridge2020

    … and causes formation of reactive oxygen species (ROS) when oxygen is resupplied. Complex I is a major source of ROS in IR injury, but also in physiological ROS signalling. The enzyme can produce ROS via reverse electron transfer (RET), which is driven by a large protonmotive force (∆p) in …

    cambridge Repository record

  3. Utilization of TMV-TEMPO as an in Vivo MRI Sensor of ROS Production in Liver Inflammation and as a DNP Agent

    Lumata, Jenica Laporca 1994-2023

    … agent for detection of reactive oxygen species (ROS) in murine model of liver inflammation and ii) its feasibility as an agent in MRI signal-enhancing dynamic nuclear polarization (DNP) technology. Chapter 1 entails discussion of the basics of magnetic resonance and hyperpolarization. Chapter 2 …

    tdl Repository record

  4. Sphingosine-1-Phosphate and Fingolimod (FTY720) Regulate ICl,swell In HL-1 Cardiac Myocytes via Intracellular Binding And Mitochondrial ROS Production

    Desai, Pooja2018

    … volume-sensitive Cl- current (ICl,swell) by ROS-dependent signaling. S1P and its analog, FTY720 (fingolimod), primarily act via G-protein coupled receptors (S1PR; S1PR1-3 in heart), but several intracellular S1P ligands are known. We investigated how these agents regulate ICl,swell. ICl,swell …

    vcu Repository record

  5. The effects of eccentric exercise on delayed onset muscle soreness, muscle function and free radical production

    Close, G LLiverpool John Moores University2004

    … recent suggestions that reactive oxygen species (ROS) may be involved in the aetiology of DOMS, however the evidence for this association is equivocal. Therefore, the aims of this thesis were to investigate the effects of unaccustomed exercise (downhill running) on DOMS, specifically investigating …

    liverpool-jm Repository record

  6. Mitochondrial metabolic suppression and reactive oxygen species production during hypometabolism in mammals

    Brown, Jason CLThe University of Western Ontario2011

    … affects mitochondrial reactive oxygen species (ROS) production, a topic which has been largely ignored previously. To accomplish these objectives, I measured in vitro respiration and ROS production rates of mitochondria from liver, skeletal muscle, and/or heart during hibernation in …

    uwo Repository record

  7. ROLE OF ENDOTHELIN-1 IN THE REGULATION OF THE SWELLING-ACTIVATED Cl- CURRENT IN ATRIAL MYOCYTES

    Deng, Wu2014

    … (AngII) signaling and reactive oxygen species (ROS) produced by NADPH oxidase (NOX) are involved in the activation of ICl, swell by both beta1-integrin stretch and osmotic swelling. Because endothelin-1 (ET-1) is a potential downstream mediator of AngII and ETA receptor blockade abrogates …

    vcu Repository record

  8. Stress responses of the marine diatom <i>Skeletonema</i> spp. to polyunsaturated aldehydes (PUAS)

    Gallina, Alessandra AlexiaThe Open University2012

    … Nitric Oxide (NO) and Reactive Oxygen Species (ROS) production in response to PUAs in <i>Skeletonema marinoi</i>, a cosmopolitan, bloom forming and PUA-producing diatom species. In the first part of the thesis I addressed the problem of whether PUA-producing species might have evolved different …

    the-open-u Repository record

  9. The relationship between glucose metabolism byproduct, D-lactate, and vascular endothelial cell dysfunction and possible role in diabetes

    Tomic, JovanaUniversity of Saskatchewan2013

    … no changes were observed. We further measured ROS production in HUV-EC-C treated with 0.06-2 mM DLA alone or 0.2 mM DLA with 5-30 mM GLU or 5-160 μM MG. All DLA concentrations increased ROS production by 160% to 216%. DLA with GLU or MG significantly increased ROS production compared to GLU or …

    sask Repository record

  10. The mechanism for paraquat toxicity involves oxidative stress and inflammation : a model for Parkinson's disease

    Miller, Rebecca Louise, 1974-University of Missouri--Columbia2007

    … examined the source of reactive oxygen species (ROS) and the underlying signaling pathway for paraquat-induced cytotoxicity to BV-2 microglial cells. Paraquat-induced ROS production was attenuate by inhibitors for NADPH oxidase, protein kinase C and extracellular signal-regulated kinases 1/2. …

    missouri Repository record

  11. The Formyl Peptide Receptor 2 Regulates Microglial Phenotype Through Immunometabolism: Implications for Alzheimer’s Disease

    Wickstead, E.University of Westminster2019

    … completely reverses reactive oxygen species (ROS) production from the mitochondria and NADPH oxidase enzymes following an inflammatory stimulus. We also highlight that the toxic oligomeric amyloid (oAβ) facilitates microglial ROS production and subsequent metabolic changes without triggering …

    westminster Repository record

  12. NUTRITION AND IMMUNITY: MOLECULAR APPROACHES

    AVILA MORALES, GABRIELA DE LOS ANGELESUniversità degli Studi di Milano2022

    … and extracellular reactive oxygen species (ROS) production was assessed. Anti-apoptotic effects and an increase in extracellular ROS production during experimental pro-inflammatory conditions were observed, only when using the mixture of the two main isomers of CLA in equal proportions …

    milano Repository record

  13. Effect of Quantum Dots, Novel Biological Imaging Agents, in Liver Cells in Vitro

    Maharjan, Utshaha2021

    … to determine the effect on cell viability, ATP production, mitochondrial membrane potential and reactive oxygen species (ROS) production. The results showed no significant effect on cell viability, ATP production and ROS production. However, the mitochondrial membrane potential of cells was …

    central-wash Repository record

  14. The impact of high and intermittent-high glucose on ROS generation and bioenergetic metabolism in vascular endothelial cells

    Shaw, AndrewUniversity of Aberdeen2015

    The overproduction of reactive oxygen species (ROS), leading to oxidative stress, is central to the induction of hyperglycaemia-mediated endothelial dysfunction and the onset of diabetes-related cardiovascular disease (CVD). In vitro treatment with high glucose is known to increase ROS production …

    uhi-uk Repository record

  15. Early hippocampal dysfunction in a mouse model of dementia with Lewy bodies: Mechanisms of cellular dysfunction caused by alpha-synuclein accumulation

    Cowan, Katrina2020

    … membrane potential and reactive oxygen species (ROS) production. The CamS120 mouse model was complemented with an alpha-synuclein overexpressing cell line (aFL), which was used to examine further changes in mitochondrial function, including changes in mitochondrial membrane potential, ROS …

    plymouth Repository record

  16. Evaluation of Endothelial Cell Responses to Elevated Glucose

    Sugerman, Gabriella2018

    … staining for Reactive Oxygen Species (ROS) production and cell viability was performed on HUVECs treated with 10.5- and 25.5-mM glucose for 24 and 48 hours. No differences in ROS production or cell viability were detected due to uncontrolled cell damage during the two-hour staining and …

    calpoly Repository record

  17. Reactive Oxygen Species are Second Messengers in the Lysophosphatidic Acid Induced Survival Signaling of Ovarian Cancer

    Saunders, Jerry Allen JrWake Forest University2009

    … positively regulated by reactive oxygen species (ROS), which are becoming increasingly recognized as having signaling capabilities. We observed that LPA causes increased ROS production in SKOV3 cancer cells, which led us to question if ROS served as second messengers in the aforementioned survival …

    wfu Repository record

  18. Analysis of the aryl hydrocarbon receptor and a truncated form (AHR C[upper case symbol for greek Delta]Δ553) in cancer cells

    Chow, Marilynn2011

    … with detoxification. Published work suggests cross-talk between both proteins and cellular pathways involving the transcription factors, HIF -1 , ER, and NFKB, whose activity is typically upregulated in cancer. This thesis focuses on using a truncated form of AhR, AhR CΔ553, which is thought to …

    u-pacific Repository record

  19. Improving antibiotic activity by manipulating bacterial reactive oxygen species metabolism

    Winkler, Jonathan AlexanderBoston University2012

    … This shared mechanism involves the metabolic production of reactive oxygen species (ROS), which can damage proteins, lipids, and nucleic acids, and can ultimately result in bacterial cell death. The body of work described here shows that this common mechanism can be exploited to improve …

    bu Repository record

  20. The Relationships of Age, Physical Activity Level, Adiposity, and Diet, with Human Satellite Myogenesis, and Metabolism

    Fausnacht, Dane WestonVirginia Tech2018

    … (fusion index), rate of reactive oxygen species (ROS) production, and capacity for substrate oxidation (glucose and fatty acid). The young group exhibited a lower proportion of body fat than the older group (22.4%±8.1 vs. 28.3%±6.3). When compared to the older group, the young group also presented …

    vt Repository record

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