Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"ROS induction"”.
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The protective role of hydrogen sulfide from obesity-associated metabolic stress in GLP-1 regulation
… caused an increase in reactive oxygen species (ROS). The H2S donor GYY4137 partially blocked PA- ROS induction. In mice, PA-enriched Western diet (WD) elevated body weight in both sexes and elevated fasting blood glucose and lipid peroxidation in males. A single GYY4137 injection improved oral …
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Genomic Analysis of Chemo-Resistance to HDAC inhibitor in Gastric Cancer cells
… of HDACi-induced reactive oxygen species (ROS) in cancer cells. The discovery of RNH1 as a regulator of HDACi resistance in gastric cancer highlights a functional role for ROS induction in the cellular effects of this important drug class
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Reaction of the marine flatworm Macrostomum lignano exposed to xenobiotics
… role in this context. The marine flatworm Macrostomum lignano is a perfect model organism for this purpose. A key mechanism of xenobiotic-induced toxicity is the formation of reactive oxygen species, which can result in cell death. This was observed in the Macrostomum model. ROS induction was …
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Investigation of anticancer activity and mechanisms of Meso- 2,3-dimercaptosuccinic acid (DMSA) in glioblastoma cell lines
… such as generation of reactive oxygen species (ROS), induction of DNA damage and cell death, inhibition of hypoxia induced stemness and epithelial to mesenchymal transition characteristics, which are the core anticancer mechanisms of DS+Cu. Collectively, our results show that DMSA+Cu induces DNA …
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Insulin-like growth factor binding protein-3 (IGFBP-3) plays an essential role in cellular senescence: molecular and clinical implications.
… onset of replicative senescence. We identified ROS accumulation in IGFBP-3/IGFBP-R-induced senescent cells which we speculated may be signaling p38 MAPK activation. Inhibition of ROS accumulation suppressed p38 signaling and prevented IGFBP-3/IGFBP-3R-induced senescence. To evaluate the sequence …
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TUNING AND TESTING DEVELOPING NEURAL NETWORKS
… multimodal impacts on calcium dynamics across the network. We study how the network-level calcium signal is impacted not only across scales but also through multiple pathways. To investigate structural interventions, we examined how global tuning of the actin cytoskeleton modulates human …
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Curbing environmental pollution of water hyacinth by using it in drug discovery
… confluency/proliferation, viability, morphology, ROS levels, and membrane integrity; (3) To evaluate functional changes in cancer cells' antioxidant stress response (ARE) promoter and tumour suppressor (p53 transcription activity) mechanisms, during extract treatment; and (4) Evaluate the effect …