Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"ROS, reactive oxygen species"”.
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Potential Roles of Peroxidases In Caenorhabditis Elegans Innate Immunity
<p>The production of ROS (reactive oxygen species) in response to pathogen detection is a rapid, nonspecific response that is evolutionarily conserved from nematodes to humans. ROS serve as direct and indirect effectors of innate and adaptive immunity. In <em>Caenorhabditis elegans</em>, a ROS …
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지적장애 환자에서 전장유전체분석으로 발견된 TFB2M 유전자 변이의 기능 연구
… 세포에 비해 아들 세포에서 산소 소모량(O2 consumption), ATP 생성량, ROS(reactive oxygen species) 생성량, 미토콘드리아 막전위가 모두 유의하게 더 높았다. 미토콘드리아 형태를 비교한 결과, 아들 세포의 미토콘드리아가 더 길고 움직임도 더 좋았다. 이러한 결과는, TFB2M c.790C>T 이형접합변이를 가진 아버지에 비하여 TFB2M c.790C>T 동형접합변이를 가진 아들 세포의 미토콘드리아 활성이 더 높다는 것을 시사한다. 환자와 아버지와 비슷한 연령의 2종의 정상인 primary …
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KGF-1 and KGF receptor expression in human periodontal disease and in vitro microwounding-associated-ligand-independent KGFR activation
… induced ligand independent KGFR activation. ROS (Reactive Oxygen Species) generation along the wound edge was associated with KGFR activation and scavenging of ROS reduced KGFR phosphorylation. The c-Src family inhibitor, PP1, significantly inhibited KGFR phosphorylation. Functionally cell …
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Fundamental Aspects Of Regenerative Cerium Oxide Nanoparticles And Their Applications In Nanobiotechnology
… in cerium oxide were correlated to increase in oxygen vacancy concentration in the cerium oxide lattice. The doping of cerium oxide nanoparticles with trivalent elements introduces more oxygen vacancies and expands the cerium oxide lattice further (in addition to the lattice expansion due to the …
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Rethinking the dithiothreitol based PM oxidative potential: measuring DTT consumption versus ROS generation
… it remains unclear. One hypothesis is that ROS (reactive oxygen species) catalyzed by ambient particulate matter will introduce excessive oxidative stress and further disrupt and destroy the cell. The thesis targeted to measure a specific ROS, hydroxyl radical (•OH) in dithiothreitol (DTT) …
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Preterm intraventricular haemorrhage - Effects of extracellular haemoglobin
… brain matter. Dysfunction of cerebrospinal fluid (CSF) production contributes to the development of PHVD but the exact molecular mechanisms remain unknown. The choroid plexus, which produces the CSF, is adjacent to the origin of IVH and is the first organ to encounter the …
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The P-Rex1 Regulator Norbin Suppressess Neutrophil-Dependent Antibacterial Immunity
… I found increased adhesion, spreading, ROS production and degranulation responses in isolated Norbin-deficient neutrophils. Moreover, Norbin-deficient neutrophils had an increased ROS-dependent capacity to kill Staphylococcus aureus. In vivo, Norbin deficiency provided increased immunity …
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The influence of acute, chronic and lifelong hypoxia on the functional and structural integrity of the neurovascular unit
… Study 1: </i>In a randomised, single-blind cross-over design, 12 healthy, physically active male participants (age, 23 ± 2 yrs; BMI, 25 ± 4 kg/m<sup>2</sup>) were exposed to 6 hours of normoxia (F<sub>I</sub>O<sub>2</sub> = 0.21) and 6 hours of acute normobaric hypoxia …
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Role of BTG2/TIS21/PC3 in differentiation of myeloid leukemia cells and its regulation under stress conditions
… close interrelation between generation of reactive oxygen species (ROS), enhanced IκBα degradation, nuclear translocation of NF-κB(p65/RelA) and the significant increase of Btg2 expression independent of p53 status. ChIP analysis revealed an enrichment of RelA (p65) bound to the κB response …
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Reactive oxygen species involvement in gabaergic dysfunction in neuropathic pain
… Oxidative stress due to excessive levels of reactive oxygen species (ROS) has been implicated in the development and maintenance of neuropathic pain. However, it is not known whether oxidative stress is related to the loss of GABAergic tone in the spinal cord. Therefore, the major goal of …