Global ETD Search
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Showing 1 to 10 of 10 for “"RNase P"”.
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Zusammensetzung eukaryotischer RNase P aus pflanzlichen Zellkernen und Plastiden
Ribonuklease P (RNaseP) ist eine essentielle Endonuklease, welche die 5'-Flanke von pre-tRNAs entfernt. In nahezu allen bisher untersuchten Organismen und Organellen besteht das Holoenzym aus einer RNA-Untereinheit und einer Protein-Komponente. Nur die Zusammensetzung des Enzyms in den …
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Substratbindung und Katalyse in RNase P RNA vom cyanobakteriellen Typ
Ribonuklease P (RNase P) ist eine essentielle Endonuklease, welche die 5'-Flanke von pre-tRNAs entfernt. Die RNase P RNA des Cyanobakteriums Prochlorococcus marinus ist in vitro katalytisch aktiv und bevorzugt in heterologen Prozessierungssystemen Substrate mit vollständigem 3’-CCA-Ende. Diese …
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Kinetic Characterization of the Coupled Folding and Binding Mechanism of Bacterial RNase P Protein: an Intrinsically Unstructured Protein
… systems. The protein component of bacterial RNase P holoenzyme from Bacillus subtilis (P protein) was used as a model system to elucidate the general folding/unfolding of an intrinsically unstructured protein (IUP) both in the absence and presence of ligands.</p><p>P protein was previously …
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Biochemical Studies of Ribonuclease P of Tetrahymena Thermophila
… substrate have been performed with the RNase P RNA subunit and holoenzymes from various sources. Experimental studies clearly reveal that the prokaryotic RNA subunit is involved in substrate binding, but that the eukaryotic RNA subunit alone is unable to bind substrate. Crosslinking …
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The RNA World: A Look at Ribonuclease P RNA, Small Nucleolar RNA, 6S RNA, and the Small Ribosomal Subunit
… RNA observed in modern cells is ribonuclease P (RNase P). RNase P is responsible for the maturation of pre-tRNA by cleaving the 5' leader to form the mature tRNA and is widely believed to be a relic from the RNA world. Other functionally important RNAs are: small nucleolar RNAs (snoRNAs) which …
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lncRNA RPPH1 in melanoma: novel functions as cargo of tumor-derived Extracellular Vesicles
… and serves as the catalytic component of the RNase P ribonucleoprotein complex. This complex performs the endonucleolytic cleavage of precursor tRNAs at their 5′ leader sequences. Increasing evidence suggests that RPPH1 may also have non-canonical roles in tumor progression, including its …
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A new approach to feature extraction for RNA structure comparision
… is tested with 118 RNA structures obtained from RNase P Database. For any two structures, it is important to identify whether they are in the same family by both structure comparison and sequence comparison. In the experiment, it is found that the method for comparing RNA structures can yield …
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Mechanismus des pre-tRNA-Spleißens : Struktur und Funktion pflanzlicher und animaler RNA-Ligasen
… der Hydrolyse der 5´- und 3´-Flanke durch die RNase P und die tRNase Z, sowie einer Vielzahl von Basenmodifizierungen, wird bei einigen pre-tRNAs das Intron herausgespleißt. Die ersten intronhaltigen tRNA Gene wurden in der Hefe Saccharomyces cerevisiae nachgewiesen und folglich wurde der …
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Characterization of The Rna Binding and Rna Degrading Subunits of The Eukaryotic Exosome
… the physiological importance of this essential RNase.</p>
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DEVELOPMENT OF SMALL MOLECULES AS INHIBITORS OF FTSZ AND RNPA ACTING AS POTENTIAL ANTIMICROBIAL AGENTS
… is able to associate with a ribozyme to form RNase P, a riboprotein complex that promotesthe removal of the 5’ leader sequence from precursor tRNA, inducing tRNA maturation. Shortly after the discovery of the essentiality of RnpA, the investigation of RnpA inhibitors as potential …