Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"RNase L"”.
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Restriction of Retrotransposition and Retroviral Infection by RNase L and APOBEC3G
The OAS/RNase L system is one of the major restriction pathways activated during the type I interferon response to viral infections. In this thesis I primarily explored its non-canonical functions beyond blocking viruses through degrading viral and cellular single-stranded RNA. Using …
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Ampligen therapy, exercise capacity and immune function in patients with chronic fatigue syndrome
… (n=7). A key finding was the normalization of RNase L. Only one subject demonstrated both a normalization in RNase L and increase in exercise performance. Trends in NK cell activity were difficult to determine. Improvements in functional capacity as measured by peak V0<sub>2</sub>were seen in …
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Cellular mechanisms associated with chemotherapy induced ribosomal RNA disruption in ovarian cancer cells
… the role of Nonfunctional RNA Decay (NRD), RNase L, autophagy, and apoptosis in chemotherapyinduced RNA disruption. Treatment of A280 ovarian carcinoma cells with a proteasome inhibitor did not reduce chemotherapy-induced RNA disruption, suggesting that NRD does not play a role. However, …
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Biogenesis of Y RNA–derived small RNAs
… (RNAi) technology, it was determined that RNase L contributed to YsRNA generation. Furthermore, the Y RNA binding protein Ro60 was shown to be essential for YsRNA production through a model of RNase protection. Analysis of deep sequencing data in Ro60 knockout cells revealed that many other …