Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"RNS-Interferenz"”.
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Molecular mechanisms governing germ line development in zebrafish and the role of this lineage in sexual differentiation
… das der Keimzellen festlegen. So ist z.B. die RNS verschiedener Keimzell-spezifischer Gene, wie vasa, nanos1 und dead end (dnd), im Keimplasma angereichert und wird in der Keimbahn expremiert.Das erste Kapitel dieser Arbeit untersucht die zelluläre Lokalisation der Proteine Dead End und Nanos1 …
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The inducible antiviral immune response of Drosophila melanogaster
… diesen drei positiv orientierten Einzelstrang RNS Viren führte zu einer starken transkriptionellen Antwort, welche deutlich virusspezifische Indukti- onsmuster zeigte. Um die biologische Signifikanz dieser beobachteten Muster zu studieren, testeten wir Mutanten verschiedener Signalwege, nämlich …
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Cell surface receptor specific delivery of short interfering RNAs via bivalent aptamer-siRNA transcripts or covalent antibody-siRNA conjugates
RNA interference (RNAi) represents an evolutionary conserved mechanism for the posttranscriptional regulation of gene expression first discovered in plants and flatworms. In higher eukaryotes posttranscriptional gene silencing is mediated by short interfering RNAs (siRNAs) that induce the sequence …
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Development of novel RNA- and protein-based cancer therapeutics by either silencing of potential oncogenes or active restoration of a tumor suppressor gene
Cancer has become more and more prevalent over the last few years, reaching its highest levels per capita in the Western world in 2008. Mutations that produce dominant gain of function oncogenes and loss of function tumor suppressor genes have been discovered due to their alteration in human and …
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Silencing of endoglin in rat hepatic stellate cells by RNA interference identifies endoglin as an important component of the transdifferentiation process
The main purpose of this doctoral thesis was the functional characterization of endoglin in hepatic stellate cells (HSC). This characterization was performed particularly with regard to the impact and the function of endoglin in the transdifferentiation process of HSC into myofibroblast-like cells …